Large neutral amino acids transporter small subunit 1

SLC7A5
Identifiers
Aliases	SLC7A5, 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1, solute carrier family 7 member 5
External IDs	OMIM: 600182; MGI: 1298205; HomoloGene: 55759; GeneCards: SLC7A5; OMA:SLC7A5 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	87,869,507 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	122,634,433 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; beta cell; ; dorsal motor nucleus of vagus nerve; ; mucosa of pharynx; ; inferior olivary nucleus; ; mucosa of esophagus; ; body of tongue; ; corpus epididymis; ; left testis; ; right testis;
	Top expressed in
	lacrimal gland; ; fetal liver hematopoietic progenitor cell; ; lens; ; seminal vesicula; ; spermatocyte; ; calvaria; ; optic nerve; ; parotid gland; ; seminiferous tubule; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide antigen binding; L-amino acid transmembrane transporter activity; amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activity; antiporter activity; protein binding; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; plasma membrane; apical plasma membrane; extracellular exosome; integral component of plasma membrane; cytoplasm; cytosol;
Biological process	amino acid transmembrane transport; cell differentiation; cellular amino acid metabolic process; nervous system development; multicellular organism development; L-amino acid transport; neutral amino acid transport; leukocyte migration; amino acid transport; L-alpha-amino acid transmembrane transport; transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8140
	20539
	ENSG00000103257
	ENSMUSG00000040010
	Q01650
	Q9Z127
	NM_003486
	NM_011404
	NP_003477
	NP_035534
	Wikidata
View/Edit Human	View/Edit Mouse

Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in humans is encoded by the SLC7A5 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000103257 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040010 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: solute carrier family 7 (cationic amino acid transporter".
"UniProt". www.uniprot.org.

Further reading

Kaira K, Oriuchi N, Imai H, et al. (2009). "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma". Lung Cancer. 66 (1): 120–6. doi:10.1016/j.lungcan.2008.12.015. PMID 19171406.
Verrey F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595. PMID 10568788. S2CID 25962115.
Nawashiro H, Otani N, Shinomiya N, et al. (2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors". Int. J. Cancer. 119 (3): 484–92. doi:10.1002/ijc.21866. PMID 16496379. S2CID 41965333.
Nawashiro H, Otani N, Uozumi Y, et al. (2005). "High expression of L-type amino acid transporter 1 in infiltrating glioma cells". Brain Tumor Pathol. 22 (2): 89–91. doi:10.1007/s10014-005-0188-z. PMID 18095110. S2CID 22818900.
Ohno Y, Suda K, Masuko K, et al. (2008). "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1". Cancer Sci. 99 (5): 1000–7. doi:10.1111/j.1349-7006.2008.00770.x. PMC 11160021. PMID 18294274. S2CID 205233796.
Vumma R, Wiesel FA, Flyckt L, et al. (2008). "Functional characterization of tyrosine transport in fibroblast cells from healthy controls". Neurosci. Lett. 434 (1): 56–60. doi:10.1016/j.neulet.2008.01.028. PMID 18262359. S2CID 25493412.
Endou H, Kanai Y (1999). "[Amino acid transporter molecule as a drug target]". Nippon Yakurigaku Zasshi. 114 (Suppl 1): 11P–16P. doi:10.1254/fpj.114.supplement_11. PMID 10629848.
Nakanishi K, Ogata S, Matsuo H, et al. (2007). "Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract". Virchows Arch. 451 (3): 681–90. doi:10.1007/s00428-007-0457-9. PMID 17622555. S2CID 2540836.
Kaira K, Oriuchi N, Imai H, et al. (2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas". J Surg Oncol. 99 (7): 433–8. doi:10.1002/jso.21277. PMID 19347882. S2CID 5381963.
Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al. (2009). "Examination of association of genes in the serotonin system to autism". Neurogenetics. 10 (3): 209–16. doi:10.1007/s10048-009-0171-7. PMC 2753863. PMID 19184136.
Ring BZ, Seitz RS, Beck RA, et al. (2009). "A novel five-antibody immunohistochemical test for subclassification of lung carcinoma". Mod. Pathol. 22 (8): 1032–43. doi:10.1038/modpathol.2009.60. PMID 19430419.
Kaira K, Oriuchi N, Imai H, et al. (2008). "Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung". Pathol. Res. Pract. 204 (8): 553–61. doi:10.1016/j.prp.2008.02.003. PMID 18440724.
Kobayashi K, Ohnishi A, Promsuk J, et al. (2008). "Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells". Neurosurgery. 62 (2): 493–503, discussion 503–4. doi:10.1227/01.neu.0000316018.51292.19. PMID 18382329.
Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306. S2CID 25402443.
Kaira K, Oriuchi N, Imai H, et al. (2008). "Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer". Br. J. Cancer. 98 (4): 742–8. doi:10.1038/sj.bjc.6604235. PMC 2259171. PMID 18253116.
Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
Kaira K, Oriuchi N, Imai H, et al. (2008). "l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms". Cancer Sci. 99 (12): 2380–6. doi:10.1111/j.1349-7006.2008.00969.x. PMC 11159766. PMID 19018776. S2CID 24560556.
Imai H, Kaira K, Oriuchi N, et al. (2009). "L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer". Histopathology. 54 (7): 804–13. doi:10.1111/j.1365-2559.2009.03300.x. PMID 19635099. S2CID 5787861.
Shennan DB, Thomson J (2008). "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells". Oncol. Rep. 20 (4): 885–9. doi:10.3892/or_00000087. PMID 18813831.
Sakata T, Ferdous G, Tsuruta T, et al. (2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer". Pathol. Int. 59 (1): 7–18. doi:10.1111/j.1440-1827.2008.02319.x. PMID 19121087. S2CID 32050759.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103257 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040010 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".

[UniProt-6] "UniProt". www.uniprot.org.

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See also

References

Further reading