SL2 RNA

SL2 RNA
SL2 RNA
	Predicted secondary structure and sequence conservation of SL2
Identifiers
Symbol	SL2
Rfam	RF00199
Other data
RNA type	Gene
Domain	Eukaryota
GO	GO:0000365
SO	SO:0000233
PDB structures	PDBe

SL2 RNA is a non-coding RNA involved in trans-splicing in lower eukaryotes. Trans-splicing is a form of RNA processing. The acquisition of a spliced leader from an SL RNA is an inter-molecular reaction which precisely joins exons derived from separately transcribed RNAs.¹ Approximately 25% of C. elegans genes are organised into polycistronic transcription units and the presence of SL2 on an mRNA is an indication the gene is in an operon.²

References

Dassanayake RS, Chandrasekharan NV, Karunanayake EH (May 2001). "Trans-spliced leader RNA, 5S-rRNA genes and novel variant orphan spliced-leader of the lymphatic filarial nematode Wuchereria bancrofti, and a sensitive polymerase chain reaction based detection assay". Gene. 269 (1–2): 185–193. doi:10.1016/S0378-1119(01)00438-3. PMID 11376950.
Evans D, Blumenthal T (September 2000). "trans splicing of polycistronic Caenorhabditis elegans pre-mRNAs: analysis of the SL2 RNA". Molecular and Cellular Biology. 20 (18): 6659–6667. doi:10.1128/MCB.20.18.6659-6667.2000. PMC 86170. PMID 10958663.

External links

Page for SL2 RNA at Rfam

[1] Dassanayake RS, Chandrasekharan NV, Karunanayake EH (May 2001). "Trans-spliced leader RNA, 5S-rRNA genes and novel variant orphan spliced-leader of the lymphatic filarial nematode Wuchereria bancrofti, and a sensitive polymerase chain reaction based detection assay". Gene. 269 (1–2): 185–193. doi:10.1016/S0378-1119(01)00438-3. PMID 11376950.

[2] Evans D, Blumenthal T (September 2000). "trans splicing of polycistronic Caenorhabditis elegans pre-mRNAs: analysis of the SL2 RNA". Molecular and Cellular Biology. 20 (18): 6659–6667. doi:10.1128/MCB.20.18.6659-6667.2000. PMC 86170. PMID 10958663.

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