SIX4

SIX4
Identifiers
Aliases	SIX4, AREC3, SIX homeobox 4
External IDs	OMIM: 606342; MGI: 106034; HomoloGene: 69089; GeneCards: SIX4; OMA:SIX4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	60,724,351 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	73,160,230 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; nasal epithelium; ; mucosa of paranasal sinus; ; cartilage tissue; ; parotid gland; ; epithelium of nasopharynx;
	Top expressed in
	lumbar spinal ganglion; ; intercostal muscle; ; maxillary prominence; ; parotid gland; ; utricle; ; foot; ; soleus muscle; ; digastric muscle; ; mandibular prominence; ; lobe of prostate;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	cytoplasm; nucleus; transcription regulator complex;
Biological process	tongue development; trigeminal ganglion development; sarcomere organization; generation of neurons; regulation of branch elongation involved in ureteric bud branching; negative regulation of apoptotic process; positive regulation of branching involved in ureteric bud morphogenesis; transcription, DNA-templated; multicellular organism development; negative regulation of satellite cell differentiation; pharyngeal system development; anatomical structure morphogenesis; embryonic skeletal system morphogenesis; inner ear morphogenesis; myotome development; fungiform papilla morphogenesis; skeletal muscle fiber differentiation; positive regulation of ureteric bud formation; regulation of gene expression; embryonic cranial skeleton morphogenesis; anatomical structure development; regulation of synaptic assembly at neuromuscular junction; olfactory placode formation; myoblast migration; thymus development; positive regulation of transcription, DNA-templated; regulation of epithelial cell proliferation; metanephric mesenchyme development; male sex determination; skeletal muscle tissue development; negative regulation of neuron apoptotic process; regulation of protein localization; male sex differentiation; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; male gonad development; negative regulation of transcription, DNA-templated; protein localization to nucleus;
	Sources:Amigo / QuickGO
Orthologs
	51804
	20474
	ENSG00000100625
	ENSMUSG00000034460
	Q9UIU6
	Q61321
	NM_017420
	NM_011382; NM_001362272
	NP_059116
	NP_035512; NP_001349201
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000100625 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034460 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S (Nov 1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies". Genomics. 61 (1): 82–91. doi:10.1006/geno.1999.5916. PMID 10512683.
Ozaki H, Yamada K, Kobayashi M, Asakawa S, Minoshima S, Shimizu N, Kajitani M, Kawakami K (May 2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes". Cytogenet Cell Genet. 87 (1–2): 108–12. doi:10.1159/000015407. PMID 10640827. S2CID 28013542.
"Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila)".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533.
Fan X, Brass LF, Poncz M, et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.
Kawakami K, Ohto H, Ikeda K, Roeder RG (1996). "Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development". Nucleic Acids Res. 24 (2): 303–10. doi:10.1093/nar/24.2.303. PMC 145635. PMID 8628654.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034460 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10512683-5] Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S (Nov 1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies". Genomics. 61 (1): 82–91. doi:10.1006/geno.1999.5916. PMID 10512683.

[pmid10640827-6] Ozaki H, Yamada K, Kobayashi M, Asakawa S, Minoshima S, Shimizu N, Kajitani M, Kawakami K (May 2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes". Cytogenet Cell Genet. 87 (1–2): 108–12. doi:10.1159/000015407. PMID 10640827. S2CID 28013542.

[entrez-7] "Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila)".

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