SH2D3A

SH2D3A
Identifiers
Aliases	SH2D3A, NSP1, SH2 domain containing 3A
External IDs	OMIM: 604721; HomoloGene: 48351; GeneCards: SH2D3A; OMA:SH2D3A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,767,463 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; olfactory bulb; ; mucosa of transverse colon; ; skin of abdomen; ; skin of leg; ; granulocyte; ; olfactory zone of nasal mucosa; ; minor salivary glands; ; body of pancreas; ; tendon of biceps brachii;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	intracellular anatomical structure;
Biological process	small GTPase mediated signal transduction; JNK cascade; positive regulation of signal transduction; positive regulation of peptidyl-serine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	10045
	n/a
	ENSG00000125731
	n/a
	Q9BRG2
	n/a
	NM_005490
	n/a
	NP_005481
	n/a
	Wikidata
View/Edit Human

SH2 domain-containing protein 3A is a protein that in humans is encoded by the SH2D3A gene.³⁴ The protein may be useful in Western Blots and ELISAs.⁵

Interactions

SH2D3A has been shown to interact with the epidermal growth factor receptor.³ The gene may play a role in JNK activation.⁶

References

GRCh38: Ensembl release 89: ENSG00000125731 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lu Y, Brush J, Stewart TA (Apr 1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry. 274 (15): 10047–52. doi:10.1074/jbc.274.15.10047. PMID 10187783.
"Entrez Gene: SH2D3A SH2 domain containing 3A".
"Recombinant Human SH2D3A Protein". potassium-channel. Potassium Channel. 1 August 2017. Retrieved 18 September 2017.
"SH2D3A Gene". genecards.org. Gene Cards. Retrieved 18 September 2017.

External links

SH2D3A human gene location in the UCSC Genome Browser.
SH2D3A human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125731 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10187783-3] Lu Y, Brush J, Stewart TA (Apr 1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry. 274 (15): 10047–52. doi:10.1074/jbc.274.15.10047. PMID 10187783.

[entrez-4] "Entrez Gene: SH2D3A SH2 domain containing 3A".

[5] "Recombinant Human SH2D3A Protein". potassium-channel. Potassium Channel. 1 August 2017. Retrieved 18 September 2017.

[6] "SH2D3A Gene". genecards.org. Gene Cards. Retrieved 18 September 2017.

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Interactions

References

Further reading

External links