Shugoshin 2

SGO2
Identifiers
Aliases	SGO2, TRIPIN, SGOL2, shugoshin 2
External IDs	OMIM: 612425; MGI: 1098767; HomoloGene: 51867; GeneCards: SGO2; OMA:SGO2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	200,584,096 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,065,058 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; sperm; ; ventricular zone; ; thymus; ; testicle; ; parietal pleura; ; gonad; ; ganglionic eminence; ; buccal mucosa cell;
	Top expressed in
	genital tubercle; ; secondary oocyte; ; zygote; ; hand; ; spermatocyte; ; medial ganglionic eminence; ; tail of embryo; ; primary oocyte; ; atrioventricular valve; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	chromosome; cytosol; chromosome, centromeric region; nucleus; kinetochore; mitotic cohesin complex; nucleoplasm; nuclear body;
Biological process	cell division; chromosome segregation; cell cycle; meiotic sister chromatid cohesion, centromeric; meiosis;
	Sources:Amigo / QuickGO
Orthologs
	151246
	68549
	ENSG00000163535
	ENSMUSG00000026039
	Q562F6
	Q7TSY8
	NM_001160033; NM_001160046; NM_152524
	NM_001177867; NM_199007
	NP_001153505; NP_001153518; NP_689737
	NP_001171338; NP_950172
	Wikidata
View/Edit Human	View/Edit Mouse

Shugoshin 2 (Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.⁵⁶⁷

Function

Shugoshin-2 is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of a multiprotein complex named cohesin.⁸ This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance.

References

GRCh38: Ensembl release 89: ENSG00000163535 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026039 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"UniProt". www.uniprot.org. Retrieved 6 November 2022.
"Entrez Gene: SGOL2 shugoshin-like 2".
Kitajima TS; Kawashima SA; Watanabe Y (February 2004). "The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis". Nature. 427 (6974): 510–7. Bibcode:2004Natur.427..510K. doi:10.1038/nature02312. PMID 14730319. S2CID 4400426.
Kitajima TS; Sakuno T; Ishiguro K; Iemura S; Natsume T; Kawashima SA; Watanabe Y (May 2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. Bibcode:2006Natur.441...46K. doi:10.1038/nature04663. PMID 16541025. S2CID 4425074.

Further reading

Hartley JL; Temple GF; Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Kitajima TS, Sakuno T, Ishiguro K, et al. (2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. Bibcode:2006Natur.441...46K. doi:10.1038/nature04663. PMID 16541025. S2CID 4425074.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163535 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026039 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[UniProt-5] "UniProt". www.uniprot.org. Retrieved 6 November 2022.

[entrez-6] "Entrez Gene: SGOL2 shugoshin-like 2".

[pmid14730319-7] Kitajima TS; Kawashima SA; Watanabe Y (February 2004). "The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis". Nature. 427 (6974): 510–7. Bibcode:2004Natur.427..510K. doi:10.1038/nature02312. PMID 14730319. S2CID 4400426.

[pmid16541025-8] Kitajima TS; Sakuno T; Ishiguro K; Iemura S; Natsume T; Kawashima SA; Watanabe Y (May 2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. Bibcode:2006Natur.441...46K. doi:10.1038/nature04663. PMID 16541025. S2CID 4425074.

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