SFRP2

SFRP2
Identifiers
Aliases	SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
External IDs	OMIM: 604157; MGI: 108078; HomoloGene: 56438; GeneCards: SFRP2; OMA:SFRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	153,789,083 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	83,681,623 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; parietal pleura; ; gallbladder; ; vena cava; ; skin of thigh; ; trachea; ; skin of hip; ; lactiferous duct; ; pericardium; ; ventricular zone;
	Top expressed in
	ascending aorta; ; aortic valve; ; calvaria; ; hand; ; endocardial cushion; ; renal corpuscle; ; condyle; ; fossa; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; receptor ligand activity; endopeptidase activator activity; integrin binding; enzyme activator activity; G protein-coupled receptor activity; Wnt-protein binding; Wnt-activated receptor activity;
Cellular component	extracellular matrix; extracellular region; extracellular space; integral component of membrane; collagen-containing extracellular matrix;
Biological process	cellular response to extracellular stimulus; positive regulation of endopeptidase activity; Wnt signaling pathway involved in somitogenesis; somitogenesis; cell differentiation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; male gonad development; regulation of establishment of planar polarity; response to nutrient; collagen fibril organization; convergent extension involved in axis elongation; development of primary male sexual characteristics; positive regulation of canonical Wnt signaling pathway; negative regulation of mesodermal cell fate specification; cellular response to X-ray; cell-cell signaling; negative regulation of Wnt signaling pathway; bone morphogenesis; hematopoietic stem cell proliferation; chondrocyte development; embryonic digit morphogenesis; outflow tract morphogenesis; cardiac left ventricle morphogenesis; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; Wnt signaling pathway; negative regulation of gene expression; sclerotome development; positive regulation of peptidyl-serine phosphorylation; positive regulation of angiogenesis; planar cell polarity pathway involved in neural tube closure; negative regulation of BMP signaling pathway; multicellular organism development; negative regulation of cardiac muscle cell apoptotic process; regulation of apoptotic process; positive regulation of cell growth; neural tube closure; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of cell migration; positive regulation of osteoblast differentiation; regulation of Wnt signaling pathway; cartilage development; regulation of cell population proliferation; regulation of stem cell division; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of cell growth; neural tube development; positive regulation of cell population proliferation; negative regulation of epithelial cell proliferation; positive regulation of apoptotic process; branching involved in blood vessel morphogenesis; post-anal tail morphogenesis; negative regulation of dermatome development; negative regulation of planar cell polarity pathway involved in axis elongation; positive regulation of cell adhesion mediated by integrin; negative regulation of transcription, DNA-templated; negative regulation of JUN kinase activity; positive regulation of fat cell differentiation; negative regulation of epithelial to mesenchymal transition; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; digestive tract morphogenesis; anterior/posterior pattern specification; apoptotic process; negative regulation of canonical Wnt signaling pathway; regulation of midbrain dopaminergic neuron differentiation; regulation of neuron projection development; G protein-coupled receptor signaling pathway; non-canonical Wnt signaling pathway; regulation of signaling receptor activity; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6423
	20319
	ENSG00000145423
	ENSMUSG00000027996
	Q96HF1
	P97299
	NM_003013
	NM_009144
	NP_003004
	NP_033170
	Wikidata
View/Edit Human	View/Edit Mouse

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.⁵⁶ This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.⁶

New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury [1].

Cancer

SFRP2 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.⁷ For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.⁷

References

GRCh38: Ensembl release 89: ENSG00000145423 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027996 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi:10.1073/pnas.94.25.13636. PMC 28358. PMID 9391078.
"Entrez Gene: SFRP2 secreted frizzled-related protein 2".
Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

Further reading

Rattner A, Hsieh JC, Smallwood PM, et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. Bibcode:1997PNAS...94.2859R. doi:10.1073/pnas.94.7.2859. PMC 20287. PMID 9096311.
Hu E, Zhu Y, Fredrickson T, et al. (1998). "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas". Biochem. Biophys. Res. Commun. 247 (2): 287–93. doi:10.1006/bbrc.1998.8784. PMID 9642118.
Lescher B, Haenig B, Kispert A (1999). "sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney". Dev. Dyn. 213 (4): 440–51. doi:10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6. PMID 9853965.
Chang JT, Esumi N, Moore K, et al. (1999). "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium". Hum. Mol. Genet. 8 (4): 575–83. doi:10.1093/hmg/8.4.575. PMID 10072424.
Lee CS, Buttitta LA, May NR, et al. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18. doi:10.1242/dev.127.1.109. PMID 10654605.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Brophy PD, Lang KM, Dressler GR (2004). "The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor". J. Biol. Chem. 278 (52): 52401–5. doi:10.1074/jbc.M305614200. PMID 14561758.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lee JL, Lin CT, Chueh LL, Chang CJ (2004). "Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis". J. Biol. Chem. 279 (15): 14602–9. doi:10.1074/jbc.M309008200. PMID 14709558.
Müller HM, Oberwalder M, Fiegl H, et al. (2004). "Methylation changes in faecal DNA: a marker for colorectal cancer screening?". Lancet. 363 (9417): 1283–5. doi:10.1016/S0140-6736(04)16002-9. PMID 15094274. S2CID 22608605.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Clément G, Braunschweig R, Pasquier N, et al. (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus". Oncogene. 25 (21): 3084–92. doi:10.1038/sj.onc.1209338. PMID 16407829.
Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Huang ZH, Li LH, Yang F, Wang JF (2007). "Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions". World J. Gastroenterol. 13 (6): 950–4. doi:10.3748/wjg.v13.i6.950. PMC 4065936. PMID 17352030.
Veeck J, Noetzel E, Bektas N, Jost E, Hartmann A, Knuchel R, Dahl E (2008). "Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer". Mol Cancer. 7 (83): 83. doi:10.1186/1476-4598-7-83. PMC 2613402. PMID 18990230.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145423 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027996 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9391078-5] Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi:10.1073/pnas.94.25.13636. PMC 28358. PMID 9391078.

[entrez-6] "Entrez Gene: SFRP2 secreted frizzled-related protein 2".

[Rotondo_2015-7] Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

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