SF1 may refer to:
Biochemistry
- SF1 (gene), a human gene
- a type of helicase, a common protein.
- Steroidogenic factor 1
Videogaming
- Star Fox (1993 video game), the first game in the Star Fox series
- Street Fighter (video game), the first game in the Street Fighter series
- SF-1 SNES TV, a television monitor sold by Sharp Corporation with a built-in Super NES
Other uses
- SRF 1, a Swiss television channel formerly known as 'SF 1'
- Summary File 1, a United States Census report
