Article · Wikipedia archive · Last revised Jun 17, 2026

Set1

Set1 is a gene that codes for Histone-lysine N-methyltransferase and H3 lysine-4 specific proteins (H3K). Set1 proteins can also be referred to as COMPASS proteins. The first H3K4 methylase, Saccharomyces cerevisiae Set1/COMPASS, is highly conserved across a multitude of phylogenies. The histone methylation facilitated by Set1 is required for cell growth and transcription silencing through the repression of RNA polymerase II. The Set1C, COMPASS Complex, also aids in transcription elongation regulation and the maintenance of telomere length.

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Jun 17, 2026
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Set1 is a gene that codes for Histone-lysine N-methyltransferase and H3 lysine-4 specific proteins (H3K).1 Set1 proteins can also be referred to as COMPASS proteins.1 The first H3K4 methylase, Saccharomyces cerevisiae Set1/COMPASS, is highly conserved across a multitude of phylogenies.2 The histone methylation facilitated by Set1 is required for cell growth and transcription silencing through the repression of RNA polymerase II.3 The Set1C, COMPASS Complex, also aids in transcription elongation regulation and the maintenance of telomere length.1

References

References

  1. "SET1 - Histone-lysine N-methyltransferase, H3 lysine-4 specific - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - SET1 gene & protein". www.uniprot.org. Retrieved 2022-04-26.
  2. Shilatifard, Ali (2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual Review of Biochemistry. 81: 65–95. doi:10.1146/annurev-biochem-051710-134100. ISSN 0066-4154. PMC 4010150. PMID 22663077.
  3. Briggs, Scott D.; Bryk, Mary; Strahl, Brian D.; Cheung, Wang L.; Davie, Judith K.; Dent, Sharon Y. R.; Winston, Fred; Allis, C. David (2001-12-15). "Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae". Genes & Development. 15 (24): 3286–3295. doi:10.1101/gad.940201. ISSN 0890-9369. PMC 312847. PMID 11751634.