SCFD1

SCFD1
Identifiers
Aliases	SCFD1, C14orf163, RA410, SLY1, SLY1P, STXBP1L2, sec1 family domain containing 1
External IDs	OMIM: 618207; MGI: 1924233; HomoloGene: 5650; GeneCards: SCFD1; OMA:SCFD1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	30,737,694 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	51,496,884 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; body of pancreas; ; anterior pituitary; ; parotid gland; ; corpus epididymis; ; oral cavity; ; mucosa of paranasal sinus; ; islet of Langerhans; ; biceps brachii; ; bone marrow cell;
	Top expressed in
	seminal vesicula; ; parotid gland; ; islet of Langerhans; ; calvaria; ; dermis; ; lobe of prostate; ; efferent ductule; ; olfactory epithelium; ; pituitary gland; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; protein binding; syntaxin binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; endoplasmic reticulum membrane; membrane; cis-Golgi network; plasma membrane; Golgi transport complex; Golgi-associated vesicle; Golgi cisterna membrane; endoplasmic reticulum;
Biological process	negative regulation of autophagosome assembly; regulation of ER to Golgi vesicle-mediated transport; response to hypoxia; regulation of protein transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; toxin transport; post-Golgi vesicle-mediated transport; vesicle docking involved in exocytosis; COPII vesicle coating; cell morphogenesis; protein transport; response to toxic substance; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	23256
	76983
	ENSG00000092108
	ENSMUSG00000020952
	Q8WVM8
	Q8BRF7
NM_001257376; NM_001283031; NM_001283032; NM_001283033; NM_016106;
	NM_182835
	NM_029825; NM_001306178
NP_001244305; NP_001269960; NP_001269961; NP_001269962; NP_057190;
	NP_878255
	NP_001293107; NP_084101
	Wikidata
View/Edit Human	View/Edit Mouse

Sec1 family domain-containing protein 1 is a protein that in humans is encoded by the SCFD1 gene.⁵

Interactions

SCFD1 has been shown to interact with USO1.⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000092108 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020952 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SCFD1 sec1 family domain containing 1".
Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
Allan BB, Moyer BD, Balch WE (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. Bibcode:2000Sci...289..444A. doi:10.1126/science.289.5478.444. PMID 10903204.

Further reading

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
Williams AL, Ehm S, Jacobson NC, Xu D, Hay JC (2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility". Mol. Biol. Cell. 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMC 307537. PMID 14565970.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC (2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 32–7. Bibcode:2003PNAS..100...32D. doi:10.1073/pnas.232701299. PMC 140874. PMID 12506202.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. CiteSeerX 10.1.1.322.2143. doi:10.1093/dnares/5.6.355. PMID 10048485.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Matsuo N, Ogawa S, Takagi T, Wanaka A, Mori T, Matsuyama T, Pinsky DJ, Stern DM, Tohyama M (1997). "Cloning of a putative vesicle transport-related protein, RA410, from cultured rat astrocytes and its expression in ischemic rat brain". J. Biol. Chem. 272 (26): 16438–44. doi:10.1074/jbc.272.26.16438. PMID 9195952.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092108 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020952 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SCFD1 sec1 family domain containing 1".

[pmid11927603-6] Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.

[pmid10903204-7] Allan BB, Moyer BD, Balch WE (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. Bibcode:2000Sci...289..444A. doi:10.1126/science.289.5478.444. PMID 10903204.

1

2

3

4

5

6

7