Article · Wikipedia archive · Last revised Jul 10, 2026

RTI-160

RTI-160 is a tropane derivative drug with stimulant effects, having similar potency as a dopamine reuptake inhibitor to cocaine. It is synthesized by an amide condensation reaction between benzoylecgonine and dimethylamine.

Last revised
Jul 10, 2026
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≈ 1 min
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Wikipedia ↗
RTI-160
Identifiers
  • [(2R,3S)-2-(Dimethylcarbamoyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] benzoate
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC18H24N2O3
Molar mass316.401 g·mol−1
3D model (JSmol)
  • CN1C2CCC1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)N(C)C
  • InChI=1S/C18H24N2O3/c1-19(2)17(21)16-14-10-9-13(20(14)3)11-15(16)23-18(22)12-7-5-4-6-8-12/h4-8,13-16H,9-11H2,1-3H3/t13?,14?,15-,16+/m0/s1
  • Key:KCJKRDUKFUVPDP-SSHXOBKSSA-N

RTI-160 (benzoylecgonine dimethylamide) is a tropane derivative drug with stimulant effects, having similar potency as a dopamine reuptake inhibitor to cocaine. It is synthesized by an amide condensation reaction between benzoylecgonine and dimethylamine.12

See also

See also

References

References

  1. Carroll FI, Kotian P, Dehghani A, Gray JL, Kuzemko MA, Parham KA, et al. (January 1995). "Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter". Journal of Medicinal Chemistry. 38 (2): 379–388. doi:10.1021/jm00002a020. PMID 7830281.
  2. Paula S, Tabet MR, Farr CD, Norman AB, Ball WJ (January 2004). "Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody". Journal of Medicinal Chemistry. 47 (1): 133–142. doi:10.1021/jm030351z. PMID 14695827.