RRN3

RRN3
Identifiers
Aliases	RRN3, A-270G1.2, TIFIA, RRN3 homolog, RNA polymerase I transcription factor
External IDs	OMIM: 605121; MGI: 1925255; HomoloGene: 39531; GeneCards: RRN3; OMA:RRN3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	15,094,311 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	13,632,703 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; gastrocnemius muscle; ; ventricular zone; ; endometrium; ; islet of Langerhans; ; rectum; ; subcutaneous adipose tissue; ; ovary; ; muscle of thigh;
	Top expressed in
	cumulus cell; ; neural tube; ; cardiac muscle tissue of left ventricle; ; epiblast; ; spermatocyte; ; morula; ; morula; ; ventricular zone; ; muscle of thigh; ; ganglionic eminence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase binding; RNA polymerase I core promoter sequence-specific DNA binding; RNA polymerase I core binding; RNA polymerase I general transcription initiation factor activity;
Cellular component	nucleolus; nucleoplasm; nucleus;
Biological process	in utero embryonic development; nucleolus organization; positive regulation of neuron projection development; regulation of transcription, DNA-templated; cell population proliferation; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; DNA-templated transcription, initiation; regulation of DNA-templated transcription, initiation; positive regulation of transcription, DNA-templated; cytoplasm organization; transcription, DNA-templated; homeostasis of number of cells; transcription initiation from RNA polymerase I promoter; ribosome biogenesis; regulation of transcription by RNA polymerase I; RNA polymerase I preinitiation complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	54700
	106298
	ENSG00000085721; ENSG00000278494
	ENSMUSG00000022682
	Q9NYV6
	B2RS91
	NM_001301064; NM_018427
	NM_001039521
	NP_001287993; NP_060897
	NP_001034610
	Wikidata
View/Edit Human	View/Edit Mouse

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene.⁵⁶⁷

Interactions

RRN3 has been shown to interact with TAF1B.⁶

References

ENSG00000278494 GRCh38: Ensembl release 89: ENSG00000085721, ENSG00000278494 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022682 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Moorefield B, Greene EA, Reeder RH (May 2000). "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4724–9. Bibcode:2000PNAS...97.4724M. doi:10.1073/pnas.080063997. PMC 18300. PMID 10758157.
Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (Mar 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
"Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, Grummt I (2000). "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p". EMBO Rep. 1 (2): 171–5. doi:10.1093/embo-reports/kvd032. PMC 1084264. PMID 11265758.
Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
Zhao J, Yuan X, Frödin M, Grummt I (2003). "ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth". Mol. Cell. 11 (2): 405–13. doi:10.1016/S1097-2765(03)00036-4. PMID 12620228.
Mayer C, Zhao J, Yuan X, Grummt I (2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.
Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P, Grummt I (2004). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID 15558034. S2CID 6633625.

[refGRCh38Ensembl-1] ENSG00000278494 GRCh38: Ensembl release 89: ENSG00000085721, ENSG00000278494 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022682 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10758157-5] Moorefield B, Greene EA, Reeder RH (May 2000). "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4724–9. Bibcode:2000PNAS...97.4724M. doi:10.1073/pnas.080063997. PMC 18300. PMID 10758157.

[pmid11250903-6] Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (Mar 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.

[entrez-7] "Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)".

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