Article · Wikipedia archive · Last revised Jun 6, 2026

Robert B. Corey

Robert B. Corey was an American biochemist, mostly known for his role in discovery of the α-helix and the β-sheet with Linus Pauling. Also working with Pauling was Herman Branson. Their discoveries were remarkably correct, with even the bond lengths being accurate until about 40 years later. The α-helix and β-sheet are two structures that are now known to form the backbones of many proteins.

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Robert B. Corey
Born(1897-08-19)August 19, 1897
DiedApril 23, 1971(1971-04-23) (aged 73)
EducationUniversity of Pittsburgh, Cornell University (Ph.D.)
Known forFirst description of the α-helix and β-sheet
Scientific career
InstitutionsCaltech
Academic advisors
Linus Pauling

Robert B. Corey (August 19, 1897 – April 23, 1971) was an American biochemist, mostly known for his role in discovery of the α-helix and the β-sheet with Linus Pauling.1 Also working with Pauling was Herman Branson. Their discoveries were remarkably correct, with even the bond lengths being accurate until about 40 years later. The α-helix and β-sheet are two structures that are now known to form the backbones of many proteins.2

Academic training

A childhood polio survivor, Corey received his undergraduate degree from the University of Pittsburgh, and his Ph.D. in chemistry from Cornell University.3

The findings of α-helix and β-sheet

At Caltech, the trio (Pauling, Corey and Branson) published a series of articles in the Proceedings of the National Academy of Sciences.45678

The most revolutionary of the articles in PNAS is the one written on February 28, 1951.8 That date was also Pauling's 50th birthday. It was called "The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain". In the paper, one odd thing is that the trio diagrammed the α-helix as a left-handed helix, although it is really a right-handed one. Another odd thing in the paper is that the 3(10) helix is almost never mentioned, although it is very common, while the γ-helix, which was another focus of the paper, is almost never found in nature.9

See also

See also

References

References

  1. "Structure of Proteins Found". The Buffalo News. 5 September 1951. p. 13.
  2. "Artificial Making of Bone, Blood and Muscle is Forecast". L.A. Daily News. p. 8.
  3. Simoni, Robert D. (1 November 2002). "Viral Proteins by X-ray Diffraction: Ralph Wyckoff and Robert Corey". The Journal of Biological Chemistry. 277 (44): 71–73. doi:10.1016/S0021-9258(19)72104-8 – via JSTOR.
  4. Pauling, L., and R. B. Corey. 1950. Two hydrogen-bonded spiral configurations of the polypeptide chain. J. Am. Chem. Soc. 72:5349.
  5. Pauling, L., and R. B. Corey. 1951. The structure of synthetic polypeptides. Proc. Natl. Acad. Sci. U.S.A. 37:241-50.
  6. Pauling, L., and R. B. Corey. 1951. The pleated sheet, a new layer configuration of polypeptide chains. Proc. Natl. Acad. Sci. U.S.A. 37:2451-56.
  7. Pauling, L., and R. B. Corey. 1953. A proposed structure for the nucleic acids. Proc. Natl. Acad. Sci. U.S.A. 39:84-97.
  8. Pauling, L., R. B. Corey, and H. R. Branson. 1951. The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chains. Proc. Natl. Acad. Sci. U.S.A. 37:205-10.
  9. "Prof. Corey's Research Has Great Value". The Republican. 5 September 1951. p. 7.
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