RNF25

RNF25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DAY, 2DMF, 5D1M, 5D1L, 5D1K
Identifiers
Aliases	RNF25, AO7, ring finger protein 25
External IDs	OMIM: 616014; MGI: 1890215; HomoloGene: 11193; GeneCards: RNF25; OMA:RNF25 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,672,002 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,640,556 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; granulocyte; ; popliteal artery; ; tibial arteries; ; prefrontal cortex; ; Descending thoracic aorta; ; left testis; ; right testis; ; stromal cell of endometrium; ; right frontal lobe;
	Top expressed in
	neural layer of retina; ; granulocyte; ; spermatid; ; superior frontal gyrus; ; yolk sac; ; seminiferous tubule; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; ubiquitin protein ligase activity; NF-kappaB binding; ubiquitin-protein transferase activity; transferase activity; protein binding;
Cellular component	cytosol; nucleus;
Biological process	positive regulation of NF-kappaB transcription factor activity; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	64320
	57751
	ENSG00000163481
	ENSMUSG00000026171
	Q96BH1
	Q9QZR0
	NM_022453
	NM_021313; NM_001305230
	NP_071898
	NP_001292159; NP_067288
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.⁵⁶

Function

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NF-κB), and modulate NF-κB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.⁶

Interactions

RNF25 has been shown to interact with RELA.⁵

References

GRCh38: Ensembl release 89: ENSG00000163481 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026171 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188.
"Entrez Gene: RNF25 ring finger protein 25".

Further reading

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. Bibcode:1999PNAS...9611364L. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163481 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026171 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12748188-5] Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188.

[entrez-6] "Entrez Gene: RNF25 ring finger protein 25".

1

2

3

4

5

6