RNF167

RNF167
Identifiers
Aliases	RNF167, 5730408C10Rik, RING105, LP2254, ring finger protein 167
External IDs	OMIM: 610431; MGI: 1917760; HomoloGene: 41046; GeneCards: RNF167; OMA:RNF167 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,945,222 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,542,247 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; apex of heart; ; mucosa of transverse colon; ; left testis; ; right testis; ; muscle layer of sigmoid colon; ; right lobe of thyroid gland; ; anterior pituitary; ; skin of abdomen; ; right hemisphere of cerebellum;
	Top expressed in
	granulocyte; ; thymus; ; lactiferous gland; ; lip; ; spleen; ; right lung; ; mesenteric lymph nodes; ; right lung lobe; ; neural layer of retina; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; endomembrane system;
Biological process	negative regulation of cell cycle; protein polyubiquitination; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	26001
	70510
	ENSG00000108523
	ENSMUSG00000040746
	Q9H6Y7
	Q91XF4
NM_015528; NM_001320356; NM_001320357; NM_001320358; NM_001320359;
	NM_001320360; NM_001320361; NM_001320362; NM_001320363; NM_001320364; NM_001320365; NM_001370303; NM_001370304; NM_001370305; NM_001370306; NM_001370307; NM_001370308; NM_001370311; NM_001370313; NM_001375485
	NM_027445; NM_001316728; NM_001363134
NP_001307285; NP_001307286; NP_001307287; NP_001307288; NP_001307289;
	NP_001307290; NP_001307291; NP_001307292; NP_001307293; NP_001307294; NP_056343; NP_001357232; NP_001357233; NP_001357234; NP_001357235; NP_001357236; NP_001357237; NP_001357240; NP_001357242; NP_001362414
	NP_001303657; NP_081721; NP_001350063
	Wikidata
View/Edit Human	View/Edit Mouse

Ring finger protein 167 is a protein that in humans is encoded by the RNF167 gene.⁵

Function

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation.⁶

References

GRCh38: Ensembl release 89: ENSG00000108523 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040746 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ring finger protein 167". Retrieved 2018-09-10.
Yamada, H. Y.; Gorbsky, G. J. (March 2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105". Oncogene. 25 (9): 1330–1339. doi:10.1038/sj.onc.1209167. ISSN 1476-5594. PMC 2713668.

Further reading

Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW (November 2012). "Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission". Proc. Natl. Acad. Sci. U.S.A. 109 (47): 19426–31. Bibcode:2012PNAS..10919426L. doi:10.1073/pnas.1217477109. PMC 3511152. PMID 23129617.
Yamazaki Y, Schönherr C, Varshney GK, Dogru M, Hallberg B, Palmer RH (February 2013). "Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation". EMBO J. 32 (4): 524–37. doi:10.1038/emboj.2013.1. PMC 3579141. PMID 23353890.
van Dijk JR, Yamazaki Y, Palmer RH (April 2014). "Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization". Biochem. J. 459 (1): 27–36. doi:10.1042/BJ20131067. PMID 24387786.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108523 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040746 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ring finger protein 167". Retrieved 2018-09-10.

[6] Yamada, H. Y.; Gorbsky, G. J. (March 2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105". Oncogene. 25 (9): 1330–1339. doi:10.1038/sj.onc.1209167. ISSN 1476-5594. PMC 2713668.

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