RNF139

RNF139
Identifiers
Aliases	RNF139, HRCA1, RCA1, TRC8, ring finger protein 139
External IDs	OMIM: 603046; MGI: 1923091; HomoloGene: 5222; GeneCards: RNF139; OMA:RNF139 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	124,488,618 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	58,778,906 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; endothelial cell; ; parietal pleura; ; visceral pleura; ; cartilage tissue; ; tail of epididymis; ; synovial joint; ; Achilles tendon;
	Top expressed in
	seminiferous tubule; ; medullary collecting duct; ; spermatid; ; renal corpuscle; ; interventricular septum; ; otolith organ; ; utricle; ; medial head of gastrocnemius muscle; ; knee joint; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; ubiquitin-like protein transferase activity; protease binding; protein binding; transferase activity; ligase activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; endoplasmic reticulum; Derlin-1 retrotranslocation complex; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; endomembrane system;
Biological process	negative regulation of translation; ERAD pathway; regulation of ER to Golgi vesicle-mediated transport; regulation of protein ubiquitination; protein polyubiquitination; regulation of protein processing; positive regulation of ubiquitin-dependent protein catabolic process; protein destabilization; protein ubiquitination; negative regulation of cell population proliferation; proteasome-mediated ubiquitin-dependent protein catabolic process; endoplasmic reticulum mannose trimming; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	11236
	75841
	ENSG00000170881
	ENSMUSG00000037075
	Q8WU17
	Q7TMV1
	NM_007218
	NM_175226
	NP_009149
	NP_780435
	Wikidata
View/Edit Human	View/Edit Mouse

RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.⁵⁶

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].⁶

References

GRCh38: Ensembl release 89: ENSG00000170881 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037075 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.
"Entrez Gene: RNF139 ring finger protein 139".

Further reading

Poland KS, Azim M, Folsom M, et al. (2007). "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma". Genes Chromosomes Cancer. 46 (9): 805–12. doi:10.1002/gcc.20466. PMID 17539022. S2CID 44344160.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Brauweiler A, Lorick KL, Lee JP, et al. (2007). "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene". Oncogene. 26 (16): 2263–71. doi:10.1038/sj.onc.1210017. PMID 17016439. S2CID 12979173.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID 12032852. S2CID 9964634.
Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. Bibcode:1999PNAS...9611364L. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170881 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037075 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9689122-5] Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.

[entrez-6] "Entrez Gene: RNF139 ring finger protein 139".

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