RNF135

RNF135
Identifiers
Aliases	RNF135, MMFD, REUL, Riplet, L13, ring finger protein 135
External IDs	OMIM: 611358; MGI: 1919206; HomoloGene: 12427; GeneCards: RNF135; OMA:RNF135 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,999,911 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,090,583 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; parietal pleura; ; synovial membrane; ; visceral pleura; ; skin of arm; ; mucosa of ileum; ; secondary oocyte; ; gingival epithelium; ; human penis; ; synovial joint;
	Top expressed in
	proximal tubule; ; right kidney; ; epithelium of small intestine; ; granulocyte; ; interventricular septum; ; utricle; ; left lobe of liver; ; spleen; ; lacrimal gland; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	ribonucleoprotein complex binding; protein binding; metal ion binding; ubiquitin-protein transferase activity; identical protein binding; transferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	positive regulation of interferon-beta production; negative regulation of type I interferon production; innate immune response; regulation of innate immune response; protein ubiquitination; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	84282
	71956
	ENSG00000181481
	ENSMUSG00000020707
	Q8IUD6
	Q9CWS1
	NM_001184992; NM_032322; NM_197939
	NM_028019
	NP_001171921; NP_115698; NP_922921
	NP_082295
	Wikidata
View/Edit Human	View/Edit Mouse

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.⁵⁶⁷

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.⁷

Interactions

RNF135 has been shown to interact with RARRES3.⁶

References

GRCh38: Ensembl release 89: ENSG00000181481 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020707 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–27. doi:10.1086/323043. PMC 1235482. PMID 11468690.
Oshiumi H, Matsumoto M, Hatakeyama S, Seya T (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem. 284 (2): 807–17. doi:10.1074/jbc.M804259200. PMID 19017631.
"Entrez Gene: RNF135 ring finger protein 135".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse". Genes Chromosomes Cancer. 37 (2): 111–20. doi:10.1002/gcc.10206. PMID 12696059. S2CID 37232718.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. hdl:2381/22044. PMID 17632510. S2CID 35797973.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181481 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020707 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11468690-5] Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–27. doi:10.1086/323043. PMC 1235482. PMID 11468690.

[pmid19017631-6] Oshiumi H, Matsumoto M, Hatakeyama S, Seya T (Jan 2009). "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection". J Biol Chem. 284 (2): 807–17. doi:10.1074/jbc.M804259200. PMID 19017631.

[entrez-7] "Entrez Gene: RNF135 ring finger protein 135".

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