RAB7B

RAB7B
Identifiers
Aliases	RAB7B, RAB7, member RAS oncogene family
External IDs	MGI: 2442295; HomoloGene: 64833; GeneCards: RAB7B; OMA:RAB7B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,003,461 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,643,177 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of abdomen; ; gingival epithelium; ; skin of leg; ; skin of thigh; ; mucosa of esophagus; ; gallbladder; ; skin of hip; ; right coronary artery; ; vagina;
	Top expressed in
	stroma of bone marrow; ; lip; ; skin of back; ; calvaria; ; epidermis; ; esophagus; ; skin of abdomen; ; umbilical cord; ; cornea; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; GTPase activity;
Cellular component	endosome; late endosome; Golgi apparatus; trans-Golgi network; lysosome; phagocytic vesicle membrane; phagocytic vesicle; membrane; cytoplasmic vesicle; late endosome membrane; vacuolar membrane;
Biological process	protein transport; negative regulation of toll-like receptor 9 signaling pathway; late endosome to Golgi transport; positive regulation of NF-kappaB transcription factor activity; positive regulation of megakaryocyte differentiation; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; cellular response to interferon-gamma; intracellular protein transport; endosome to lysosome transport; Rab protein signal transduction; phagosome-lysosome fusion;
	Sources:Amigo / QuickGO
Orthologs
	338382
	226421
	ENSG00000276600
	ENSMUSG00000052688
	Q96AH8
	Q8VEA8
	NM_001164522; NM_001304839; NM_177403
	NM_145509; NM_001311096
	NP_001157994; NP_001291768; NP_796377
	NP_001298025; NP_663484
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.⁵

Function

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.⁶ By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.⁶

References

GRCh38: Ensembl release 89: ENSG00000276600 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000052688 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID 15144907.
Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID 17395780. S2CID 28664736.

Further reading

Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000276600 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052688 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15144907-5] Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID 15144907.

[pmid17395780-6] Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID 17395780. S2CID 28664736.

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