Article · Wikipedia archive · Last revised Jun 24, 2026

Pyrinuron

Pyrinuron is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.

Last revised
Jun 24, 2026
Read time
≈ 1 min
Length
247 w
Citations
4
Source
Wikipedia ↗
Pyrinuron
source ↗
Names
Preferred IUPAC name
N-(4-Nitrophenyl)-N′-[(pyridin-3-yl)methyl]urea
Other names
Pyriminil
Vacor
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.053.279
UNII
  • InChI=1S/C13H12N4O3/c18-13(15-9-10-2-1-7-14-8-10)16-11-3-5-12(6-4-11)17(19)20/h1-8H,9H2,(H2,15,16,18) checkY
    Key: CLKZWXHKFXZIMA-UHFFFAOYSA-N checkY
  • InChI=1/C13H12N4O3/c18-13(15-9-10-2-1-7-14-8-10)16-11-3-5-12(6-4-11)17(19)20/h1-8H,9H2,(H2,15,16,18)
    Key: CLKZWXHKFXZIMA-UHFFFAOYAA
  • [O-][N+](=O)c1ccc(cc1)NC(=O)NCc2cccnc2
Properties
C13H12N4O3
Molar mass 272.264 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Toxic
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide.1 Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States.2 If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes.2 The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.3

References

References

  1. Vogel, R. P. (1982). "Poisoning with Vacor Rodenticide". Archives of Pathology and Laboratory Medicine. 106 (3): 153. PMID 6895844.
  2. "Pyriminil". U.S. National Library of Medicine. Archived from the original on 2013-07-04. Retrieved 2013-11-04.
  3. Loreto, Andrea; Angeletti, Carlo; Gu, Weixi; Osborne, Andrew; Nieuwenhuis, Bart; Gilley, Jonathan; Arthur-Farraj, Peter; Merlini, Elisa; Amici, Adolfo; Luo, Zhenyao; Hartley-Tassell, Lauren (2021). "Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1". eLife. 10 e72823. bioRxiv 10.1101/2020.09.18.304261. doi:10.7554/eLife.72823. PMC 8758145. PMID 34870595.