PWP2

PWP2
Identifiers
Aliases	PWP2, EHOC-17, PWP2H, UTP1, PWP2 periodic tryptophan protein homolog (yeast), small subunit processome component, PWP2 small subunit processome component
External IDs	OMIM: 601475; MGI: 1341200; HomoloGene: 136786; GeneCards: PWP2; OMA:PWP2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	44,131,181 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	78,020,983 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; corpus callosum; ; mucosa of transverse colon; ; gastric mucosa; ; gonad; ; skeletal muscle tissue; ; sural nerve; ; prefrontal cortex; ; right adrenal gland; ; blood;
	Top expressed in
	primitive streak; ; epiblast; ; primary oocyte; ; otic vesicle; ; secondary oocyte; ; otic placode; ; cumulus cell; ; zygote; ; ventricular zone; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	snoRNA binding; RNA binding;
Cellular component	Pwp2p-containing subcomplex of 90S preribosome; nucleus; nucleolus; small-subunit processome; nucleoplasm;
Biological process	ribosomal small subunit assembly; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	5822
	110816
	ENSG00000241945
	ENSMUSG00000032834
	Q15269
	Q8BU03
	NM_005049
	NM_029546
	NP_005040
	NP_083822
	Wikidata
View/Edit Human	View/Edit Mouse

Periodic tryptophan protein 2 homolog is a protein that in humans is encoded by the PWP2 gene.⁵⁶

Function

This protein is involved in the assembly of small subunit of ribosome.⁶

References

GRCh38: Ensembl release 89: ENSG00000241945 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032834 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yamakawa K, Gao DQ, Korenberg JR (Dec 1996). "A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3". Cytogenet Cell Genet. 74 (1–2): 140–5. doi:10.1159/000134402. PMID 8893822.
"PWP2 PWP2 small subunit processome component [ Homo sapiens (human) ]".

Further reading

Lalioti MD, Chen H, Rossier C, et al. (1996). "Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3". Genomics. 35 (2): 321–7. doi:10.1006/geno.1996.0363. PMID 8661145.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Lafrenière RG, Rochefort DL, Chrétien N, et al. (1997). "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3". Genome Res. 6 (12): 1216–26. doi:10.1101/gr.6.12.1216. PMID 8973917.
Nagamine K, Kudoh J, Kawasaki K, et al. (1997). "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3". Biochem. Biophys. Res. Commun. 235 (1): 185–90. Bibcode:1997BBRC..235..185N. doi:10.1006/bbrc.1997.6758. PMID 9196060.
Nagamine K, Kudoh J, Minoshima S, et al. (1997). "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21". Genomics. 42 (3): 528–31. doi:10.1006/geno.1997.4761. PMID 9205129.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241945 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032834 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8893822-5] Yamakawa K, Gao DQ, Korenberg JR (Dec 1996). "A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3". Cytogenet Cell Genet. 74 (1–2): 140–5. doi:10.1159/000134402. PMID 8893822.

[entrez-6] "PWP2 PWP2 small subunit processome component [ Homo sapiens (human) ]".

1

2

3

4

5

6