PTPN18

PTPN18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OC3, 4GFU, 4GFV, 4NND
Identifiers
Aliases	PTPN18, BDP1, PTP-HSCF, protein tyrosine phosphatase, non-receptor type 18, protein tyrosine phosphatase non-receptor type 18
External IDs	OMIM: 606587; MGI: 108410; HomoloGene: 74971; GeneCards: PTPN18; OMA:PTPN18 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	130,375,405 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	34,514,814 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right uterine tube; ; mucosa of transverse colon; ; rectum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; spleen; ; tendon of biceps brachii; ; body of pancreas;
	Top expressed in
	granulocyte; ; thymus; ; blood; ; spleen; ; mesenteric lymph nodes; ; submandibular gland; ; tibiofemoral joint; ; duodenum; ; lacrimal gland; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; non-membrane spanning protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine phosphatase activity;
Cellular component	nucleus; cytoplasm; cytosol; nucleoplasm;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; dephosphorylation; ERBB2 signaling pathway; negative regulation of ERBB signaling pathway; cellular response to cytokine stimulus; blastocyst formation;
	Sources:Amigo / QuickGO
Orthologs
	26469
	19253
	ENSG00000072135
	ENSMUSG00000026126
	Q99952
	Q61152
	NM_001142370; NM_014369
	NM_011206
	NP_001135842; NP_055184
	NP_035336
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.⁵⁶

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. It has been shown that nuclear import of PTPN18 can suppress the formation of tumors during breast cancer.⁷⁸ The biological function of this PTP has not yet been determined.⁶

Interactions

PTPN18 has been shown to interact with PSTPIP1.⁹

References

GRCh38: Ensembl release 89: ENSG00000072135 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026126 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kim YW, Wang H, Sures I, Lammers R, Martell KJ, Ullrich A (January 1997). "Characterization of the PEST family protein tyrosine phosphatase BDP1". Oncogene. 13 (10): 2275–2279. PMID 8950995.
"Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)".
Wang T, Ba X, Zhang X, Zhang N, Wang G, Bai B, et al. (18 August 2022). "Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2". Nature. 13 (720).
Zhang N, Wang T, Bai B, Zhang X, Xu W, Chen W, et al. (30 December 2025). "PTPN18 functions as a tumor suppressor in breast cancer by negatively regulating cyclin E". International Journal of Oncology. 68 (3).
Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, et al. (August 1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". The Journal of Cell Biology. 138 (4): 845–860. doi:10.1083/jcb.138.4.845. PMC 2138048. PMID 9265651.

Further reading

Dowbenko D, Spencer S, Quan C, Lasky LA (1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". The Journal of Biological Chemistry. 273 (2): 989–996. doi:10.1074/jbc.273.2.989. PMID 9422760.
Wu Y, Dowbenko D, Lasky LA (1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". The Journal of Biological Chemistry. 273 (46): 30487–30496. doi:10.1074/jbc.273.46.30487. PMID 9804817.
Wang B, Lemay S, Tsai S, Veillette A (2001). "SH2 Domain-Mediated Interaction of Inhibitory Protein Tyrosine Kinase Csk with Protein Tyrosine Phosphatase-HSCF". Molecular and Cellular Biology. 21 (4): 1077–1088. doi:10.1128/MCB.21.4.1077-1088.2001. PMC 99562. PMID 11158295.
Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, et al. (December 2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Molecular Cell. 6 (6): 1413–1423. doi:10.1016/S1097-2765(00)00138-6. PMID 11163214.
Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, et al. (April 2002). "Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder". Human Molecular Genetics. 11 (8): 961–969. doi:10.1093/hmg/11.8.961. PMID 11971877.
Shiota M, Tanihiro T, Nakagawa Y, Aoki N, Ishida N, Miyazaki K, et al. (April 2003). "Protein tyrosine phosphatase PTP20 induces actin cytoskeleton reorganization by dephosphorylating p190 RhoGAP in rat ovarian granulosa cells stimulated with follicle-stimulating hormone". Molecular Endocrinology. 17 (4). Baltimore, Md.: 534–549. doi:10.1210/me.2002-0187. PMID 12554790.
Gensler M, Buschbeck M, Ullrich A (2004). "Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1". The Journal of Biological Chemistry. 279 (13): 12110–12116. doi:10.1074/jbc.M309527200. PMID 14660651.
Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML (January 2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1). San Diego, Calif.: 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, et al. (September 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Molecular & Cellular Proteomics. 4 (9): 1240–1250. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, et al. (August 2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nature Methods. 2 (8): 591–598. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
Gandhi TK, Chandran S, Peri S, Saravana R, Amanchy R, Prasad TS, et al. (2005). "A bioinformatics analysis of protein tyrosine phosphatases in humans". DNA Research. 12 (2): 79–89. doi:10.1093/dnares/12.2.79. PMID 16303740.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072135 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026126 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Kim_1997-5] Kim YW, Wang H, Sures I, Lammers R, Martell KJ, Ullrich A (January 1997). "Characterization of the PEST family protein tyrosine phosphatase BDP1". Oncogene. 13 (10): 2275–2279. PMID 8950995.

[entrez-6] "Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)".

[7] Wang T, Ba X, Zhang X, Zhang N, Wang G, Bai B, et al. (18 August 2022). "Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2". Nature. 13 (720).

[8] Zhang N, Wang T, Bai B, Zhang X, Xu W, Chen W, et al. (30 December 2025). "PTPN18 functions as a tumor suppressor in breast cancer by negatively regulating cyclin E". International Journal of Oncology. 68 (3).

[Spencer_1997-9] Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, et al. (August 1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". The Journal of Cell Biology. 138 (4): 845–860. doi:10.1083/jcb.138.4.845. PMC 2138048. PMID 9265651.

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