PRSS22

PRSS22
Identifiers
Aliases	PRSS22, BSSP-4, hBSSP-4, SP001LA, protease, serine 22, serine protease 22
External IDs	OMIM: 609343; MGI: 1918085; HomoloGene: 23344; GeneCards: PRSS22; OMA:PRSS22 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,858,170 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,217,074 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; minor salivary glands; ; gallbladder; ; body of pancreas; ; right uterine tube; ; prostate; ; tonsil; ; vagina; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	conjunctival fornix; ; lip; ; transitional epithelium of urinary bladder; ; cornea; ; superior cervical ganglion; ; epithelium of lens; ; external carotid artery; ; esophagus; ; internal carotid artery; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type endopeptidase activity; hydrolase activity; serine-type peptidase activity;
Cellular component	extracellular region; extrinsic component of plasma membrane; anchored component of plasma membrane;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	64063
	70835
	ENSG00000005001; ENSG00000282937
	ENSMUSG00000045027
	Q9GZN4
	Q9ER10
	NM_022119
	NM_133731
	NP_071402
	NP_598492
	Wikidata
View/Edit Human	View/Edit Mouse

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.⁵⁶⁷

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.⁵

References

ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000045027 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: protease".
Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi:10.1074/jbc.M108677200. PMID 11602603.
Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood. 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC 1895090. PMID 15701722.

Further reading

Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Martin J, Han C, Gordon LA, et al. (2004). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
Mitsui S, Okui A, Kominami K, et al. (2005). "A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells". FEBS J. 272 (19): 4911–23. doi:10.1111/j.1742-4658.2005.04901.x. PMID 16176265. S2CID 25290079.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: protease".

[pmid11602603-6] Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells". J. Biol. Chem. 276 (52): 49169–82. doi:10.1074/jbc.M108677200. PMID 11602603.

[pmid15701722-7] Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22". Blood. 105 (10): 3893–901. doi:10.1182/blood-2003-10-3501. PMC 1895090. PMID 15701722.

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See also

References

Further reading