PRPF19

PRPF19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LG8
Identifiers
Aliases	PRPF19, NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4, pre-mRNA processing factor 19
External IDs	OMIM: 608330; MGI: 106247; HomoloGene: 6421; GeneCards: PRPF19; OMA:PRPF19 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	60,906,585 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,886,923 bp
RNA expression pattern
	Top expressed in
	pons; ; right frontal lobe; ; Brodmann area 9; ; ventricular zone; ; ganglionic eminence; ; prefrontal cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; anterior pituitary; ; islet of Langerhans;
	Top expressed in
	aortic valve; ; primitive streak; ; motor neuron; ; ascending aorta; ; fossa; ; right ventricle; ; epiblast; ; Paneth cell; ; facial motor nucleus; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; protein binding; identical protein binding; transferase activity;
Cellular component	site of double-strand break; nuclear speck; catalytic step 2 spliceosome; membrane; lipid droplet; spindle; Prp19 complex; DNA replication factor A complex; spliceosomal complex; cytoskeleton; nucleus; cytoplasm; nucleoplasm; U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome;
Biological process	mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; lipid biosynthetic process; negative regulation of neuron differentiation; positive regulation of astrocyte differentiation; positive regulation of mRNA splicing, via spliceosome; protein K63-linked ubiquitination; mRNA processing; protein polyubiquitination; inner cell mass cell proliferation; cellular response to DNA damage stimulus; spliceosomal complex assembly; protein ubiquitination; proteasomal protein catabolic process; transcription-coupled nucleotide-excision repair; double-strand break repair via nonhomologous end joining; DNA repair; RNA splicing; generation of catalytic spliceosome for first transesterification step; positive regulation of neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	27339
	28000
	ENSG00000110107
	ENSMUSG00000024735
	Q9UMS4
	Q99KP6
	NM_014502
	NM_001253843; NM_001253844; NM_134129
	NP_055317
	NP_001240772; NP_001240773; NP_598890
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.⁵⁶

In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM]⁶

Interactions

PRPF19 has been shown to interact with CDC5L.⁷

References

GRCh38: Ensembl release 89: ENSG00000110107 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024735 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mahajan KN, Mitchell BS (September 2003). "Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase". Proc Natl Acad Sci U S A. 100 (19): 10746–51. Bibcode:2003PNAS..10010746M. doi:10.1073/pnas.1631060100. PMC 196874. PMID 12960389.
"Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)".
Ajuh P, Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading

Gerner C, Holzmann K, Meissner M, et al. (1999). "Reassembling proteins and chaperones in human nuclear matrix protein fractions". J. Cell. Biochem. 74 (2): 145–51. doi:10.1002/(SICI)1097-4644(19990801)74:2<145::AID-JCB1>3.0.CO;2-#. PMID 10404385. S2CID 196598497.
Gotzmann J, Gerner C, Meissner M, et al. (2000). "hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions". Exp. Cell Res. 261 (1): 166–79. doi:10.1006/excr.2000.5025. PMID 11082287.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Makarova OV, Makarov EM, Urlaub H, et al. (2004). "A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing". EMBO J. 23 (12): 2381–91. doi:10.1038/sj.emboj.7600241. PMC 423283. PMID 15175653.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Löscher M, Fortschegger K, Ritter G, et al. (2005). "Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome". Biochem. J. 388 (Pt 2): 593–603. doi:10.1042/BJ20041517. PMC 1138967. PMID 15660529.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhang N, Kaur R, Lu X, et al. (2006). "The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links". J. Biol. Chem. 280 (49): 40559–67. doi:10.1074/jbc.M508453200. PMID 16223718.
Grillari J, Ajuh P, Stadler G, et al. (2005). "SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly". Nucleic Acids Res. 33 (21): 6868–83. doi:10.1093/nar/gki986. PMC 1310963. PMID 16332694.
Voglauer R, Chang MW, Dampier B, et al. (2006). "SNEV overexpression extends the life span of human endothelial cells". Exp. Cell Res. 312 (6): 746–59. doi:10.1016/j.yexcr.2005.11.025. PMID 16388800.
Lu X, Legerski RJ (2007). "The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage". Biochem. Biophys. Res. Commun. 354 (4): 968–74. doi:10.1016/j.bbrc.2007.01.097. PMC 1810354. PMID 17276391.
Fortschegger K, Wagner B, Voglauer R, et al. (2007). "Early embryonic lethality of mice lacking the essential protein SNEV". Mol. Cell. Biol. 27 (8): 3123–30. doi:10.1128/MCB.01188-06. PMC 1899945. PMID 17283042.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110107 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024735 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12960389-5] Mahajan KN, Mitchell BS (September 2003). "Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase". Proc Natl Acad Sci U S A. 100 (19): 10746–51. Bibcode:2003PNAS..10010746M. doi:10.1073/pnas.1631060100. PMC 196874. PMID 12960389.

[entrez-6] "Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)".

[pmid11101529-7] Ajuh P, Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

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