Article · Wikipedia archive · Last revised Jun 22, 2026

Propanamide

Propanamide has the chemical formula CH3CH2C=O(NH2). It is the amide of propanoic acid.

Last revised
Jun 22, 2026
Read time
≈ 1 min
Length
277 w
Citations
2
Source
Propanamide
Skeletal formula
Skeletal formula source ↗
Ball-and-stick model
Ball-and-stick model source ↗
Names
Preferred IUPAC name
Propanamide
Other names
n-propylamide
Propionamide
Propylamide
Propionic amide
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.001.066
EC Number
  • 201-182-6
MeSH C034666
UNII
  • InChI=1S/C3H7NO/c1-2-3(4)5/h2H2,1H3,(H2,4,5) ☒N
    Key: QLNJFJADRCOGBJ-UHFFFAOYSA-N ☒N
  • InChI=1/C3H7NO/c1-2-3(4)5/h2H2,1H3,(H2,4,5)
    Key: QLNJFJADRCOGBJ-UHFFFAOYAE
  • CCC(=O)N
Properties
C3H7NO
Molar mass 73.095 g·mol−1
Appearance liquid, yellow
Density 1.042 g/mL
Melting point 80 °C (176 °F; 353 K)
Boiling point 213 °C (415 °F; 486 K)
very soluble in water
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Propanamide has the chemical formula CH3CH2C=O(NH2).1 It is the amide of propanoic acid.

This organic compound is a mono-substituted amide.2 Organic compounds of the amide group can react in many different organic processes to form other useful compounds for synthesis.

Preparation

Propanamide can be prepared by the condensation reaction between urea and propanoic acid:

(NH2)2CO + 2 CH3CH2COOH → 2CH3CH2CO(NH2) + H2O + CO2

or by the dehydration of ammonium propionate:

(NH4)CH3CH2COO → CH3CH2CONH2 + H2O

Reactions

Propanamide being an amide can participate in a Hofmann rearrangement to produce ethylamine gas.

References

References

  1. Ramazani, Ali; Rouhani, Morteza; Joo, Sang Woo (2016-01-01). "Catalyst-free sonosynthesis of highly substituted propanamide derivatives in water". Ultrasonics Sonochemistry. 28: 393–399. Bibcode:2016UltS...28..393R. doi:10.1016/j.ultsonch.2015.08.019. ISSN 1350-4177. PMID 26384923.
  2. Ye, Xuewei; Chai, Weiyun; Lian, Xiao-Yuan; Zhang, Zhizhen (2017-06-18). "Novel propanamide analogue and antiproliferative diketopiperazines from mangrove Streptomyces sp. Q24". Natural Product Research. 31 (12): 1390–1396. doi:10.1080/14786419.2016.1253079. ISSN 1478-6419. PMID 27806640. S2CID 24563632.