Article · Wikipedia archive · Last revised Jun 22, 2026

Prolintane

Prolintane is a central nervous system (CNS) stimulant and norepinephrine–dopamine reuptake inhibitor (NDRI) of the phenylalkylpyrrolidine family developed in the 1950s. Being an amphetamine derivative, it is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine, and has a similar mechanism of action. Many cases of prolintane abuse have been reported.

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Jun 22, 2026
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Prolintane
Clinical data
Trade namesCatovit, Katovit, Promotil, Villescon
Routes of
administration		By mouth, intranasal, rectal
Drug classStimulant; Norepinephrine–dopamine reuptake inhibitor (NDRI)
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • BR: Class B1 (Psychoactive drugs)1
Identifiers
  • 1-(1-phenylpentan-2-yl)pyrrolidine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.007.077
Chemical and physical data
FormulaC15H23N
Molar mass217.356 g·mol−1
3D model (JSmol)
Melting point133 °C (271 °F)
Boiling point153 °C (307 °F)
  • CCCC(N1CCCC1)CC2=CC=CC=C2
  • InChI=1S/C15H23N/c1-2-8-15(16-11-6-7-12-16)13-14-9-4-3-5-10-14/h3-5,9-10,15H,2,6-8,11-13H2,1H3 checkY
  • Key:OJCPSBCUMRIPFL-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Prolintane is a central nervous system (CNS) stimulant2 and norepinephrine–dopamine reuptake inhibitor (NDRI) of the phenylalkylpyrrolidine family developed in the 1950s.3 Being an amphetamine derivative, it is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine, and has a similar mechanism of action.4 Many cases of prolintane abuse have been reported.5

Under the brand name Katovit, prolintane was commercialized by the Spanish pharmaceutical company FHER until 2001. It was most often used by students and workers as a stimulant to provide energy and increase alertness and concentration.6 Prolintane and substituted prolintane analogs (fluoro and methyl) show DAT and NET inhibition in the low nanomolar range, which is consistent with NDRI psychostimulants such a methylphenidate.6 In addition 4-substituted analogs have SERT inhibition which correlates with amphetamine SAR such as fenfluramine.6

See also

See also

References

References

  1. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. Hollister LE, Gillespie HK (March–April 1970). "A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers". The Journal of Clinical Pharmacology and the Journal of New Drugs. 10 (2): 103–109. doi:10.1177/009127007001000205. PMID 4392006.
  3. GB 807835, "New tertiary amines and their salts and process for their preparation", published 1959-01-21, assigned to Dr Karl Thomae GmbH and Boehringer Ingelheim Pharma GmbH and Co KG 
  4. Nicholson AN, Stone BM, Jones MM (November 1980). "Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline". British Journal of Clinical Pharmacology. 10 (5): 465–472. doi:10.1111/j.1365-2125.1980.tb01790.x. PMC 1430138. PMID 7437258.
  5. Kyle PB, Daley WP (September 2007). "Domestic abuse of the European rave drug prolintane". Journal of Analytical Toxicology. 31 (7): 415–418. doi:10.1093/jat/31.7.415. PMID 17725890.
  6. Kastner N, Islam MN, Dybek M, Roth E, Heisinger S, Holy M, et al. (December 2025). "Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences". The Journal of Biological Chemistry. 301 (12) 110903. doi:10.1016/j.jbc.2025.110903. PMC 12720098. PMID 41197716.