PRIM1

PRIM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BPU, 4BPW, 4BPX, 4LIK, 4LIL, 4MHQ, 4RR2, 5EXR
Identifiers
Aliases	PRIM1, p49, primase (DNA) subunit 1, DNA primase subunit 1
External IDs	OMIM: 176635; MGI: 97757; HomoloGene: 730; GeneCards: PRIM1; OMA:PRIM1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,752,374 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,865,906 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; ganglionic eminence; ; ventricular zone; ; bone marrow; ; bone marrow cell; ; rectum; ; Achilles tendon; ; lymph node; ; islet of Langerhans;
	Top expressed in
	medial ganglionic eminence; ; fetal liver hematopoietic progenitor cell; ; genital tubercle; ; vas deferens; ; maxillary prominence; ; primitive streak; ; mandibular prominence; ; internal carotid artery; ; condyle; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; transferase activity; nucleotidyltransferase activity; metal ion binding; single-stranded DNA binding; DNA primase activity;
Cellular component	membrane; nucleoplasm; alpha DNA polymerase:primase complex; primosome complex;
Biological process	DNA replication; G1 phase; DNA replication initiation; DNA replication, synthesis of RNA primer; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5557
	19075
	ENSG00000198056
	ENSMUSG00000025395
	P49642
	P20664
	NM_000946
	NM_008921
	NP_000937
	NP_032947
	Wikidata
View/Edit Human	View/Edit Mouse

DNA primase small subunit is in humans is encoded by the PRIM1 gene and is part of the enzyme DNA polymerase alpha.⁵

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit.

References

GRCh38: Ensembl release 89: ENSG00000198056 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025395 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.

External links

Overview of all the structural information available in the PDB for UniProt: P49642 (Human DNA primase small subunit (PRIM1)) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198056 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025395 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530050-5] Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.

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References

Further reading

External links