Lipoblast

A lipoblast is a precursor cell for an adipocyte.¹ Alternate terms include adipoblast² and preadipocyte.³ Early stages are almost indistinguishable from fibroblasts.⁴

Lipoblasts (white arrow) and lipocytes (black arrow), in a case of lipoblastoma
Micrograph showing a lipoblast (left-bottom of image) in a liposarcoma. H&E stain.
Histopathology of liposarcoma, H&E stain, with the main features:⁵
- Spindle cells with enlarged, hyperchromatic nuclei.
- Apparently univacuolated adipocytes (may look normal).
- Lipoblasts (multivacuolated), but neither necessary nor sufficient for diagnosis of liposarcoma.
Lipid-laden histiocytes may mimic lipoblasts, but have lightly eosinophilic cytoplasm and a small normochromatic nuclei which are not hollowed out from the lipid vacuoles.⁶

Liposarcoma

Lipoblasts are seen in liposarcoma⁷ and characteristically have abundant multivacuolated clear cytoplasm and a dark staining (hyperchromatic), indented nucleus.

References

Barbara Young; Paul R. Wheater (2006). Wheater's functional histology: a text and colour atlas. Elsevier Health Sciences. pp. 74–. ISBN 978-0-443-06850-8. Retrieved 18 April 2010.
Dani C (1999). "Embryonic stem cell-derived adipogenesis". Cells Tissues Organs (Print). 165 (3–4): 173–80. doi:10.1159/000016697. PMID 10592389. S2CID 41201445.
Coskun H, Summerfield TL, Kniss DA, Friedman A (April 2010). "Mathematical modeling of preadipocyte fate determination". J Theor Biol. 265 (1): 87–94. Bibcode:2010JThBi.265...87C. doi:10.1016/j.jtbi.2010.03.047. PMID 20385145.
Ray C. Henrikson; Gordon I. Kaye; Joseph E. Mazurkiewicz (31 July 1997). Histology. Lippincott Williams & Wilkins. pp. 118–. ISBN 978-0-683-06225-0. Retrieved 18 April 2010.
Michael R. Clay, M.D. "Liposarcoma". PathologyOutlines. Topic Completed: 1 November 2017. Minor changes: 11 May 2021
Image by Mikael Häggström, MD. Reference for findings: Gnepp, Douglas R. (2009). Diagnostic Surgical Pathology of the Head and Neck. Philadelphia, PA: Saunders. ISBN 978-1-4160-2589-4.
Lester J. Layfield (2002). Cytopathology of bone and soft tissue tumors. Oxford University Press US. pp. 83–. ISBN 978-0-19-513236-6. Retrieved 18 April 2010.

[YoungWheater2006-1] Barbara Young; Paul R. Wheater (2006). Wheater's functional histology: a text and colour atlas. Elsevier Health Sciences. pp. 74–. ISBN 978-0-443-06850-8. Retrieved 18 April 2010.

[pmid10592389-2] Dani C (1999). "Embryonic stem cell-derived adipogenesis". Cells Tissues Organs (Print). 165 (3–4): 173–80. doi:10.1159/000016697. PMID 10592389. S2CID 41201445.

[pmid20385145-3] Coskun H, Summerfield TL, Kniss DA, Friedman A (April 2010). "Mathematical modeling of preadipocyte fate determination". J Theor Biol. 265 (1): 87–94. Bibcode:2010JThBi.265...87C. doi:10.1016/j.jtbi.2010.03.047. PMID 20385145.

[HenriksonKaye1997-4] Ray C. Henrikson; Gordon I. Kaye; Joseph E. Mazurkiewicz (31 July 1997). Histology. Lippincott Williams & Wilkins. pp. 118–. ISBN 978-0-683-06225-0. Retrieved 18 April 2010.

[PathologyOutlines-5] Michael R. Clay, M.D. "Liposarcoma". PathologyOutlines. Topic Completed: 1 November 2017. Minor changes: 11 May 2021

[6] Image by Mikael Häggström, MD. Reference for findings: Gnepp, Douglas R. (2009). Diagnostic Surgical Pathology of the Head and Neck. Philadelphia, PA: Saunders. ISBN 978-1-4160-2589-4.

[Layfield2002-7] Lester J. Layfield (2002). Cytopathology of bone and soft tissue tumors. Oxford University Press US. pp. 83–. ISBN 978-0-19-513236-6. Retrieved 18 April 2010.

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Liposarcoma

See also

References