PPP1CC

PPP1CC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IT6, 1JK7, 1U32, 2BCD, 2BDX, 4UT2, 4UT3
Identifiers
Aliases	PPP1CC, PP-1G, PP1C, PPP1G, protein phosphatase 1 catalytic subunit gamma
External IDs	OMIM: 176914; MGI: 3647492; HomoloGene: 100608; GeneCards: PPP1CC; OMA:PPP1CC - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	110,742,939 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,175,273 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right ventricle; ; parotid gland; ; Skeletal muscle tissue of biceps brachii; ; secondary oocyte; ; superficial temporal artery; ; duodenum; ; male germ cell; ; skin of hip; ; sperm;
	Top expressed in
	neural layer of retina; ; spermatocyte; ; spermatid; ; genital tubercle; ; epiblast; ; tail of embryo; ; olfactory bulb; ; ventricular zone; ; ganglionic eminence; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; protein domain specific binding; protein N-terminus binding; phosphatase activity; protein-containing complex binding; protein serine/threonine phosphatase activity; metal ion binding; protein phosphatase 1 binding; protein C-terminus binding; protein binding; protein phosphatase binding; hydrolase activity; protein kinase binding; lamin binding; RNA binding;
Cellular component	cytoplasm; cytosol; nuclear speck; focal adhesion; dendritic spine; chromosome; nucleoplasm; mitochondrial outer membrane; midbody; PTW/PP1 phosphatase complex; nucleolus; mitochondrion; cleavage furrow; chromosome, centromeric region; nucleus; kinetochore; protein phosphatase type 1 complex; protein-containing complex; presynapse; postsynapse; glutamatergic synapse;
Biological process	regulation of nucleocytoplasmic transport; rhythmic process; protein dephosphorylation; circadian regulation of gene expression; cell division; regulation of circadian rhythm; neuron differentiation; glycogen metabolic process; cell cycle; entrainment of circadian clock by photoperiod; sister chromatid cohesion; carbohydrate metabolic process; positive regulation of glial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	5501
	434233
	ENSG00000186298
	ENSMUSG00000004455
	P36873
	P63087
	NM_001244974; NM_002710
	XM_006508415
	NP_001231903; NP_002701
	NP_038664
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.⁵

Interactions

PPP1CC has been shown to interact with PPP1R15A,⁶⁷ SMARCB1,⁶ TLX1⁸ and PPP1R9B.⁹¹⁰

References

GRCh38: Ensembl release 89: ENSG00000186298 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000004455 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform".
Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.
Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.
Kawabe T, Muslin A J, Korsmeyer S J (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615). ENGLAND: 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. S2CID 608633.
Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). UNITED STATES: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
Smith FD, Oxford G S, Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28). UNITED STATES: 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.

Further reading

Van Eynde A, Wera S, Beullens M, et al. (1996). "Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing". J. Biol. Chem. 270 (47): 28068–74. doi:10.1074/jbc.270.47.28068. PMID 7499293.
Egloff MP, Cohen PT, Reinemer P, Barford D (1996). "Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate". J. Mol. Biol. 254 (5): 942–59. doi:10.1006/jmbi.1995.0667. PMID 7500362.
MacKintosh RW, Dalby KN, Campbell DG, et al. (1995). "The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1". FEBS Lett. 371 (3): 236–40. doi:10.1016/0014-5793(95)00888-G. PMID 7556599. S2CID 42021604.
Norman SA, Mott DM (1994). "Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA". Mamm. Genome. 5 (1): 41–5. doi:10.1007/BF00360567. PMID 8111128. S2CID 21566111.
Barker HM, Craig SP, Spurr NK, Cohen PT (1993). "Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2". Biochim. Biophys. Acta. 1178 (2): 228–33. doi:10.1016/0167-4889(93)90014-G. PMID 8394140.
Helps NR, Barker HM, Elledge SJ, Cohen PT (1996). "Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53". FEBS Lett. 377 (3): 295–300. doi:10.1016/0014-5793(95)01347-4. PMID 8549741. S2CID 3010008.
Saadat M, Nomoto K, Mizuno Y, et al. (1996). "Assignment of the gene encoding type 1 gamma protein phosphatase catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes". Jpn. J. Hum. Genet. 41 (1): 159–65. doi:10.1007/BF01892623. PMID 8914631.
Armstrong CG, Browne GJ, Cohen P, Cohen PT (1998). "PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1". FEBS Lett. 418 (1–2): 210–4. doi:10.1016/S0014-5793(97)01385-9. PMID 9414128. S2CID 21169749.
Andreassen PR, Lacroix FB, Villa-Moruzzi E, Margolis RL (1998). "Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells". J. Cell Biol. 141 (5): 1207–15. doi:10.1083/jcb.141.5.1207. PMC 2137188. PMID 9606212.
Ajuh PM, Browne GJ, Hawkes NA, et al. (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318.
Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif". J. Biol. Chem. 275 (30): 22635–44. doi:10.1074/jbc.M003082200. PMID 10807923.
Katayama H, Zhou H, Li Q, et al. (2002). "Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle". J. Biol. Chem. 276 (49): 46219–24. doi:10.1074/jbc.M107540200. PMID 11551964.
Patel KG, Liu C, Cameron PL, Cameron RS (2001). "Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1". J. Neurosci. 21 (20): 7954–68. doi:10.1523/JNEUROSCI.21-20-07954.2001. PMC 6763852. PMID 11588169.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Jones JA, Hannun YA (2002). "Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid". J. Biol. Chem. 277 (18): 15530–8. doi:10.1074/jbc.M111555200. PMID 11856740.
Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.
Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat". Virology. 296 (1): 6–16. doi:10.1006/viro.2002.1438. PMID 12036313.
Tan SL, Tareen SU, Melville MW, et al. (2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation". J. Biol. Chem. 277 (39): 36109–17. doi:10.1074/jbc.M205109200. PMID 12138106.
Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation". J. Biol. Chem. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186298 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004455 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform".

[pmid12016208-6] Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.

[pmid11564868-7] Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.

[pmid9009195-8] Kawabe T, Muslin A J, Korsmeyer S J (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615). ENGLAND: 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. S2CID 608633.

[pmid10194355-9] Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). UNITED STATES: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.

[pmid10391935-10] Smith FD, Oxford G S, Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28). UNITED STATES: 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.

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