PPIP5K2

PPIP5K2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T54, 3T7A, 3T99, 3T9A, 3T9B, 3T9C, 3T9D, 3T9E, 3T9F, 4HN2, 4NZM, 4NZN, 4NZO, 4Q4C, 4Q4D, 5BYA, 5BYB
Identifiers
Aliases	PPIP5K2, HISPPD1, IP7K2, VIP2, CFAP160, diphosphoinositol pentakisphosphate kinase 2, DFNB100
External IDs	OMIM: 611648; MGI: 2142810; HomoloGene: 49409; GeneCards: PPIP5K2; OMA:PPIP5K2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	103,212,799 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	97,770,411 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; sural nerve; ; bone marrow cell; ; tibia; ; monocyte; ; rectum; ; ventricular zone; ; Descending thoracic aorta; ; left ovary;
	Top expressed in
	hand; ; superior cervical ganglion; ; interventricular septum; ; epithelium of small intestine; ; secondary oocyte; ; zygote; ; myocardium of ventricle; ; tail of embryo; ; genital tubercle; ; migratory enteric neural crest cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	inositol hexakisphosphate 5-kinase activity; transferase activity; inositol hexakisphosphate 1-kinase activity; nucleotide binding; diphosphoinositol-pentakisphosphate kinase activity; inositol-1,3,4,5,6-pentakisphosphate kinase activity; inositol hexakisphosphate 3-kinase activity; kinase activity; inositol hexakisphosphate kinase activity; ATP binding; inositol heptakisphosphate kinase activity; 5-diphosphoinositol pentakisphosphate 3-kinase activity;
Cellular component	cytoplasm; cytosol;
Biological process	inositol phosphate metabolic process; phosphorylation; inositol phosphate biosynthetic process; inositol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23262
	227399
	ENSG00000145725
	ENSMUSG00000040648
	O43314
	Q6ZQB6
NM_001276277; NM_001281471; NM_015216; NM_001345871; NM_001345872;
	NM_001345873; NM_001345874; NM_001345875; NM_001345876; NM_001345877; NM_001345878
	NM_173760
NP_001263206; NP_001268400; NP_001332800; NP_001332801; NP_001332802;
	NP_001332803; NP_001332804; NP_001332805; NP_001332806; NP_001332807; NP_056031
NP_776121; NP_001392387; NP_001392388; NP_001392389; NP_001392390;
	NP_001392391; NP_001392392; NP_001392393; NP_001392394; NP_001392395; NP_001392396; NP_001392397; NP_001392398; NP_001392399; NP_001392400; NP_001392401; NP_001392402
	Wikidata
View/Edit Human	View/Edit Mouse

Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene. ⁵

Function

Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.

HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).

References

GRCh38: Ensembl release 89: ENSG00000145725 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040648 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2". Retrieved 2017-03-21.

Further reading

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Wang H, Falck JR, Hall TM, Shears SB (2011). "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding". Nat. Chem. Biol. 8 (1): 111–6. doi:10.1038/nchembio.733. PMC 3923263. PMID 22119861.
Weaver JD, Wang H, Shears SB (2013). "The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment". Biosci. Rep. 33 (2): e00022. doi:10.1042/BSR20120115. PMC 3564036. PMID 23240582.
Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB (2015). "Identification of a functional nuclear translocation sequence in hPPIP5K2". BMC Cell Biol. 16: 17. doi:10.1186/s12860-015-0063-7. PMC 4472268. PMID 26084399.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145725 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040648 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2". Retrieved 2017-03-21.

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