PPIL4

PPIL4
Identifiers
Aliases	PPIL4, HDCME13P, peptidylprolyl isomerase like 4
External IDs	OMIM: 607609; MGI: 1914668; HomoloGene: 12126; GeneCards: PPIL4; OMA:PPIL4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,546,043 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,698,899 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; testicle; ; left ovary; ; gonad; ; ventricular zone; ; right ovary; ; endometrium; ; islet of Langerhans; ; thymus;
	Top expressed in
	saccule; ; otic vesicle; ; otic placode; ; zygote; ; primitive streak; ; granulocyte; ; pituitary gland; ; seminal vesicula; ; neural layer of retina; ; blood;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	isomerase activity; nucleic acid binding; RNA binding; peptidyl-prolyl cis-trans isomerase activity;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	protein peptidyl-prolyl isomerization; regulation of phosphorylation of RNA polymerase II C-terminal domain;
	Sources:Amigo / QuickGO
Orthologs
	85313
	67418
	ENSG00000131013
	ENSMUSG00000015757
	Q8WUA2
	Q9CXG3
	NM_139126
	NM_026141
	NP_624311
	NP_080417
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene.⁵

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.⁵

References

GRCh38: Ensembl release 89: ENSG00000131013 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000015757 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4".

Further reading

Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell Genet. 95 (1–2): 43–7. doi:10.1159/000057015. PMID 11978968. S2CID 35018873.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131013 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015757 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4".

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