Powless is a surname. People with that name include:
- Delby Powless (born 1980), Mohawk lacrosse player
- Gaylord Powless (1946–2001), Canadian lacrosse player
- Neilson Powless (born 1996), American cyclist
- John Powless (1932–2021), American basketball and tennis coach
- Johnny Powless (born 1993), Canadian lacrosse player
- Neal Powless, American lacrosse player
- Paul Powless (1758–1847), Oneida warrior and chief
- Purcell Powless (1925–2010), Oneida tribal chairman
- Ross Powless (1926–2003), Mohawk lacrosse player
- Shayna Powless (born 1994), American racing cyclist