POU3F1

POU3F1
Identifiers
Aliases	POU3F1, OCT6, OTF6, SCIP, POU class 3 homeobox 1
External IDs	OMIM: 602479; MGI: 101896; HomoloGene: 135923; GeneCards: POU3F1; OMA:POU3F1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	38,046,793 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,554,448 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; tibial nerve; ; skin of leg; ; gonad; ; skin of arm; ; Region I of hippocampus proper; ; gums; ; caudate nucleus; ; sural nerve; ; putamen;
	Top expressed in
	Region I of hippocampus proper; ; barrel cortex; ; skin of external ear; ; dorsal striatum; ; ganglionic eminence; ; female urethra; ; medial ganglionic eminence; ; hair follicle; ; nucleus accumbens; ; hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; transcription coactivator activity; DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus; nucleoplasm;
Biological process	axon ensheathment; regulation of transcription by RNA polymerase II; myelination; forebrain development; Schwann cell development; brain development; regulation of transcription, DNA-templated; transcription, DNA-templated; myelination in peripheral nervous system; keratinocyte differentiation; positive regulation of transcription by RNA polymerase II; epidermis development; positive regulation of transcription, DNA-templated; positive regulation of gene expression; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5453
	18991
	ENSG00000185668
	ENSMUSG00000090125
	Q03052
	P21952
	NM_002699
	NM_011141
	NP_002690
	NP_035271
	Wikidata
View/Edit Human	View/Edit Mouse

POU domain, class 3, transcription factor 1 (also known as Oct-6) is a protein that in humans is encoded by the POU3F1 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000185668 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000090125 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tobler A, Schreiber E, Fontana A (Feb 1993). "The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart". Nucleic Acids Research. 21 (4): 1043. doi:10.1093/nar/21.4.1043. PMC 309249. PMID 8451175.
"Entrez Gene: POU3F1 POU domain, class 3, transcription factor 1".

Further reading

Monuki ES, Kuhn R, Weinmaster G, Trapp BD, Lemke G (Sep 1990). "Expression and activity of the POU transcription factor SCIP". Science. 249 (4974): 1300–3. Bibcode:1990Sci...249.1300M. doi:10.1126/science.1975954. PMID 1975954.
Suzuki N, Rohdewohld H, Neuman T, Gruss P, Schöler HR (Nov 1990). "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain". The EMBO Journal. 9 (11): 3723–32. doi:10.1002/j.1460-2075.1990.tb07585.x. PMC 552128. PMID 1976514.
Zwilling S, König H, Wirth T (Mar 1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors". The EMBO Journal. 14 (6): 1198–208. doi:10.1002/j.1460-2075.1995.tb07103.x. PMC 398197. PMID 7720710.
Leger H, Sock E, Renner K, Grummt F, Wegner M (Jul 1995). "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y". Molecular and Cellular Biology. 15 (7): 3738–47. doi:10.1128/mcb.15.7.3738. PMC 230612. PMID 7791781.
Faus I, Hsu HJ, Fuchs E (May 1994). "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia". Molecular and Cellular Biology. 14 (5): 3263–75. doi:10.1128/mcb.14.5.3263. PMC 358693. PMID 7909356.
Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E (Oct 1995). "Expression of transcription regulating genes in human preimplantation embryos". Human Reproduction. 10 (10): 2787–92. doi:10.1093/oxfordjournals.humrep.a135792. PMID 8567814.
Jaegle M, Mandemakers W, Broos L, Zwart R, Karis A, Visser P, Grosveld F, Meijer D (Jul 1996). "The POU factor Oct-6 and Schwann cell differentiation". Science. 273 (5274): 507–10. Bibcode:1996Sci...273..507J. doi:10.1126/science.273.5274.507. PMID 8662541. S2CID 39349653.
Sock E, Enderich J, Rosenfeld MG, Wegner M (Jul 1996). "Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6". The Journal of Biological Chemistry. 271 (29): 17512–8. doi:10.1074/jbc.271.29.17512. PMID 8663425.
Malik KF, Jaffe H, Brady J, Young WS (Apr 1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U". Brain Research. Molecular Brain Research. 45 (1): 99–107. doi:10.1016/S0169-328X(96)00238-0. PMID 9105675.
Sumiyama K, Washio-Watanabe K, Ono T, Yoshida MC, Hayakawa T, Ueda S (Feb 1998). "Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2". Mammalian Genome. 9 (2): 180–1. doi:10.1007/s003359900721. PMID 9457692. S2CID 9495282.
Arroyo EJ, Bermingham JR, Rosenfeld MG, Scherer SS (Oct 1998). "Promyelinating Schwann cells express Tst-1/SCIP/Oct-6". The Journal of Neuroscience. 18 (19): 7891–902. doi:10.1523/JNEUROSCI.18-19-07891.1998. PMC 6792991. PMID 9742157.
Kawasaki T, Oka N, Tachibana H, Akiguchi I, Shibasaki H (Mar 2003). "Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies". Acta Neuropathologica. 105 (3): 203–8. doi:10.1007/s00401-002-0630-9. hdl:2433/148771. PMID 12557005. S2CID 2340303.
Beck IM, Müller M, Mentlein R, Sadowski T, Mueller MS, Paus R, Sedlacek R (May 2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". The Journal of Investigative Dermatology. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.
Ryu EJ, Wang JY, Le N, Baloh RH, Gustin JA, Schmidt RE, Milbrandt J (Oct 2007). "Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss". The Journal of Neuroscience. 27 (43): 11552–9. doi:10.1523/JNEUROSCI.5497-06.2007. PMC 6673231. PMID 17959798.

External links

POU3F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185668 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090125 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8451175-5] Tobler A, Schreiber E, Fontana A (Feb 1993). "The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart". Nucleic Acids Research. 21 (4): 1043. doi:10.1093/nar/21.4.1043. PMC 309249. PMID 8451175.

[entrez-6] "Entrez Gene: POU3F1 POU domain, class 3, transcription factor 1".

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See also

References

Further reading

External links