Polyamine-modulated factor 1

PMF1
Identifiers
Aliases	PMF1, polyamine modulated factor 1
External IDs	OMIM: 609176; MGI: 1914287; HomoloGene: 5224; GeneCards: PMF1; OMA:PMF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,240,042 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,317,638 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; apex of heart; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; right auricle of heart; ; ectocervix; ; skin of leg; ; left ventricle; ; granulocyte;
	Top expressed in
	yolk sac; ; embryo; ; embryo; ; ventricular zone; ; tibiofemoral joint; ; blastocyst; ; internal carotid artery; ; lip; ; morula; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; leucine zipper domain binding; protein binding;
Cellular component	chromosome; cytosol; MIS12/MIND type complex; chromosome, centromeric region; nucleus; kinetochore; transcription regulator complex; nucleoplasm; Golgi apparatus; intracellular membrane-bounded organelle; nuclear MIS12/MIND complex;
Biological process	chromosome segregation; cell division; cell cycle; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	11243
	67037
	ENSG00000160783
	ENSMUSG00000028066
	Q6P1K2
	Q9CPV5
	NM_007221; NM_001199653; NM_001199654
	NM_025928; NM_001310605
	NP_001186582; NP_001186583; NP_009152
	NP_001297534; NP_080204
	Wikidata
View/Edit Human	View/Edit Mouse

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.⁵⁶

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.⁷⁸

References

GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.
"Entrez Gene: PMF1 polyamine-modulated factor 1".
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.

Further reading

Wang Y, Devereux W, Stewart TM, Casero RA (April 2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". The Biochemical Journal. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC 1221710. PMID 11256947.
Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". The Biochemical Journal. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (April 2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". The Journal of Cell Biology. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10419538-5] Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.

[entrez-6] "Entrez Gene: PMF1 polyamine-modulated factor 1".

[pmid15371340-7] Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.

[pmid15502821-8] Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.

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