PLXNB3

PLXNB3
Identifiers
Aliases	PLXNB3, PLEXB3, PLEXR, PLXN6, plexin B3
External IDs	OMIM: 300214; MGI: 2154240; HomoloGene: 68468; GeneCards: PLXNB3; OMA:PLXNB3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	153,779,346 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,772,514 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; tibial nerve; ; right hemisphere of cerebellum; ; hippocampus proper; ; substantia nigra; ; putamen; ; primary visual cortex; ; temporal lobe; ; amygdala; ; caudate nucleus;
	Top expressed in
	deep cerebellar nuclei; ; pontine nuclei; ; superior colliculus; ; substantia nigra; ; lumbar subsegment of spinal cord; ; lateral geniculate nucleus; ; globus pallidus; ; ventral tegmental area; ; sciatic nerve; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	semaphorin receptor activity; Rho GDP-dissociation inhibitor binding; protein domain specific binding; protein binding; cell-cell adhesion mediator activity;
Cellular component	integral component of membrane; membrane; plasma membrane; cell surface; semaphorin receptor complex; integral component of plasma membrane;
Biological process	negative regulation of cell adhesion; positive regulation of endothelial cell proliferation; positive regulation of axonogenesis; nervous system development; negative regulation of cell migration; negative regulation of GTPase activity; regulation of cell shape; cell chemotaxis; positive chemotaxis; semaphorin-plexin signaling pathway; signal transduction; negative regulation of lamellipodium assembly; positive regulation of neuron projection development; homophilic cell adhesion via plasma membrane adhesion molecules; axon extension; regulation of cell migration; regulation of GTPase activity; semaphorin-plexin signaling pathway involved in axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	5365
	140571
	ENSG00000198753
	ENSMUSG00000031385
	Q9ULL4
	Q9QY40
	NM_005393; NM_001163257
	NM_019587
	NP_001156729; NP_005384
	NP_062533
	Wikidata
View/Edit Human	View/Edit Mouse

Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene.⁵⁶

Interactions

PLXNB3 has been shown to interact with ARHGEF11.⁷⁸

References

GRCh38: Ensembl release 89: ENSG00000198753 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031385 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
"Entrez Gene: PLXNB3 plexin B3".
Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading

Sandoval N, Bauer D, Brenner V, Coy JF, Drescher B, Kioschis P, Korn B, Nyakatura G, Poustka A, Reichwald K, Rosenthal A, Platzer M (Jul 1996). "The genomic organization of a human creatine transporter (CRTR) gene located in Xq28". Genomics. 35 (2): 383–5. doi:10.1006/geno.1996.0373. PMID 8661155.
Brenner V, Nyakatura G, Rosenthal A, Platzer M (Aug 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (Jul 2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888. S2CID 24596233.
Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L (Jul 2004). "Plexin-B3 is a functional receptor for semaphorin 5A". EMBO Reports. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC 1299100. PMID 15218527.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U (2006). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin". BMC Neuroscience. 6 53. doi:10.1186/1471-2202-6-53. PMC 1215486. PMID 16122393.
Rujescu D, Meisenzahl EM, Krejcova S, Giegling I, Zetzsche T, Reiser M, Born CM, Möller HJ, Veske A, Gal A, Finckh U (Feb 2007). "Plexin B3 is genetically associated with verbal performance and white matter volume in human brain". Molecular Psychiatry. 12 (2): 190–4, 115. doi:10.1038/sj.mp.4001903. PMID 17033634. S2CID 2406935.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198753 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031385 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10520995-5] Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.

[entrez-6] "Entrez Gene: PLXNB3 plexin B3".

[pmid12183458-7] Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.

[pmid12123608-8] Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

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