PLK2

PLK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4I5M, 4I5P, 4I6B, 4I6F, 4I6H, 4RS6, 4XB0
Identifiers
Aliases	PLK2, SNK, hPlk2, hSNK, polo like kinase 2
External IDs	OMIM: 607023; MGI: 1099790; HomoloGene: 21317; GeneCards: PLK2; OMA:PLK2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	58,460,139 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	110,537,378 bp
RNA expression pattern
	Top expressed in
	spleen; ; apex of heart; ; canal of the cervix; ; ectocervix; ; islet of Langerhans; ; epithelium of colon; ; skin of abdomen; ; Achilles tendon; ; gallbladder; ; tibial nerve;
	Top expressed in
	CA3 field; ; Region I of hippocampus proper; ; perirhinal cortex; ; entorhinal cortex; ; primary motor cortex; ; primary visual cortex; ; olfactory tubercle; ; choroid plexus of fourth ventricle; ; superior frontal gyrus; ; left lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein-containing complex binding; signal transducer activity; ATP-dependent protein binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	cytoplasm; centrosome; cell projection; intracellular anatomical structure; dendrite; centriole; chromatin; cytoskeleton; cytosol;
Biological process	positive regulation of protein catabolic process; positive regulation of autophagy; phosphorylation; mitotic cell cycle checkpoint signaling; G1 phase; mitotic spindle organization; Rap protein signal transduction; regulation of centriole replication; negative regulation of apoptotic process; memory; regulation of synaptic plasticity; protein phosphorylation; peptidyl-serine phosphorylation; long-term depression; mitotic cell cycle; positive regulation of I-kappaB kinase/NF-kappaB signaling; Ras protein signal transduction; positive regulation of protein binding; negative regulation of dendritic spine development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; long-term potentiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	10769
	20620
	ENSG00000145632
	ENSMUSG00000021701
	Q9NYY3
	P53351
	NM_006622; NM_001252226
	NM_152804
	NP_001239155; NP_006613
	NP_690017
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.⁵

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. [supplied by OMIM]⁵

References

GRCh38: Ensembl release 89: ENSG00000145632 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021701 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)".

Further reading

Kauselmann G, Weiler M, Wulff P, et al. (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297.
Ouyang B, Li W, Pan H, et al. (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
Holtrich U, Wolf G, Yuan J, et al. (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene. 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900.
Liby K, Wu H, Ouyang B, et al. (2002). "Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase". DNA Seq. 11 (6): 527–33. doi:10.3109/10425170109041337. PMID 11696980. S2CID 46552280.
Shimizu-Yoshida Y, Sugiyama K, Rogounovitch T, et al. (2002). "Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells". Biochem. Biophys. Res. Commun. 289 (2): 491–8. doi:10.1006/bbrc.2001.5993. PMID 11716500.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB". Mol. Cancer Res. 1 (5): 376–84. PMID 12651910.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Burns TF, Fei P, Scata KA, et al. (2003). "Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells". Mol. Cell. Biol. 23 (16): 5556–71. doi:10.1128/MCB.23.16.5556-5571.2003. PMC 166320. PMID 12897130.
Ma S, Charron J, Erikson RL (2003). "Role of Plk2 (Snk) in mouse development and cell proliferation". Mol. Cell. Biol. 23 (19): 6936–43. doi:10.1128/MCB.23.19.6936-6943.2003. PMC 193943. PMID 12972611.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yogosawa S, Hatakeyama S, Nakayama KI, et al. (2006). "Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase". J. Biol. Chem. 280 (50): 41619–27. doi:10.1074/jbc.M508397200. PMID 16203730.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Park YY, Kim SH, Kim YJ, et al. (2007). "Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma)". Biochem. Biophys. Res. Commun. 362 (1): 107–13. Bibcode:2007BBRC..362..107P. doi:10.1016/j.bbrc.2007.07.170. PMID 17706602.
Matthew EM, Yen TJ, Dicker DT, et al. (2007). "Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells". Cell Cycle. 6 (20): 2571–8. doi:10.4161/cc.6.20.5079. PMID 17912033.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145632 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021701 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)".

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