PI4K2B

PI4K2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WTV
Identifiers
Aliases	PI4K2B, PI4KIIB, PIK42B, phosphatidylinositol 4-kinase type 2 beta
External IDs	OMIM: 612101; MGI: 1914323; HomoloGene: 32405; GeneCards: PI4K2B; OMA:PI4K2B - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	25,279,204 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	52,926,682 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; duodenum; ; skin of arm; ; mucosa of ileum; ; epithelium of nasopharynx; ; liver; ; pancreatic epithelial cell; ; mucosa of paranasal sinus; ; rectum;
	Top expressed in
	left lung lobe; ; lacrimal gland; ; decidua; ; epithelium of small intestine; ; gastrula; ; parotid gland; ; jejunum; ; intestinal villus; ; right lung; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; ATP binding; kinase activity; 1-phosphatidylinositol 4-kinase activity;
Cellular component	cytosol; membrane; cytoplasm; lysosomal membrane; endosome; trans-Golgi network; plasma membrane;
Biological process	phosphatidylinositol biosynthetic process; phosphorylation; Golgi organization; endosome organization; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	55300
	67073
	ENSG00000038210
	ENSMUSG00000029186
	Q8TCG2
	Q8CBQ5
	NM_018323
	NM_025951; NM_028744
	NP_060793
	NP_080227; NP_083020
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol 4-kinase type 2-beta is an enzyme that in humans is encoded by the PI4K2B gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000038210 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029186 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T (May 2002). "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments". J Biol Chem. 277 (22): 20041–50. doi:10.1074/jbc.M111807200. PMID 11923287.
"Entrez Gene: PI4K2B phosphatidylinositol 4-kinase type 2 beta".

Further reading

Griffioen M, van der Meijden ED, Slager EH, et al. (2008). "Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3837–42. Bibcode:2008PNAS..105.3837G. doi:10.1073/pnas.0712250105. PMC 2268788. PMID 18316730.
Jones DR, Bultsma Y, Keune WJ, et al. (2006). "Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta". Mol. Cell. 23 (5): 685–95. doi:10.1016/j.molcel.2006.07.014. PMID 16949365.
Srivastava R, Sinha RK, Subrahmanyam G (2006). "Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain in Jurkat cells". Mol. Immunol. 43 (5): 454–63. doi:10.1016/j.molimm.2005.03.009. PMID 16337488.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wei YJ, Sun HQ, Yamamoto M, et al. (2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP". J. Biol. Chem. 277 (48): 46586–93. doi:10.1074/jbc.M206860200. PMID 12324459.
Mora S, Durham PL, Smith JR, et al. (2002). "NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway". J. Biol. Chem. 277 (30): 27494–500. doi:10.1074/jbc.M203669200. hdl:2445/176737. PMID 12011096.
Huang C, Handlogten ME, Miller RT (2002). "Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor". J. Biol. Chem. 277 (23): 20293–300. doi:10.1074/jbc.M200831200. PMID 11907035.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000038210 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029186 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11923287-5] Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T (May 2002). "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments". J Biol Chem. 277 (22): 20041–50. doi:10.1074/jbc.M111807200. PMID 11923287.

[entrez-6] "Entrez Gene: PI4K2B phosphatidylinositol 4-kinase type 2 beta".

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