PHF12

PHF12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L9S, 2LKM
Identifiers
Aliases	PHF12, PF1, PHD finger protein 12
External IDs	MGI: 1924057; HomoloGene: 10841; GeneCards: PHF12; OMA:PHF12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,951,771 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,921,365 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; bone marrow cell; ; stromal cell of endometrium; ; spleen; ; right lung; ; blood; ; appendix; ; gastric mucosa; ; ganglionic eminence;
	Top expressed in
	genital tubercle; ; tail of embryo; ; neural layer of retina; ; granulocyte; ; ventricular zone; ; zygote; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; thymus; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription corepressor binding; histone binding; transcription corepressor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; protein binding; phosphatidylinositol binding; metal ion binding;
Cellular component	transcription repressor complex; Sin3 complex; nucleus; nucleoplasm; Sin3-type complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	57649
	268448
	ENSG00000109118
	ENSMUSG00000037791
	Q96QT6
	Q5SPL2
	NM_001033561; NM_001290131; NM_020889
	NM_174852
	NP_001028733; NP_001277060; NP_065940
	NP_777277
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene.⁵⁶

Interactions

PHF12 has been shown to interact with SIN3A.⁵

References

GRCh38: Ensembl release 89: ENSG00000109118 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037791 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yochum GS, Ayer DE (July 2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex". Molecular and Cellular Biology. 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.
"Entrez Gene: PHF12 PHD finger protein 12".

Further reading

Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Yochum GS, Ayer DE (November 2002). "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Molecular and Cellular Biology. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" (PDF). DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. S2CID 43194324.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109118 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037791 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11390640-5] Yochum GS, Ayer DE (July 2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex". Molecular and Cellular Biology. 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.

[entrez-6] "Entrez Gene: PHF12 PHD finger protein 12".

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