Protein pelota homolog

PELO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X52
Identifiers
Aliases	PELO, PRO1770, CGI-17, pelota homolog (Drosophila), pelota mRNA surveillance and ribosome rescue factor
External IDs	OMIM: 605757; MGI: 2145154; HomoloGene: 6835; GeneCards: PELO; OMA:PELO - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	52,804,044 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	115,226,722 bp
RNA expression pattern
	Top expressed in
	vena cava; ; decidua; ; saphenous vein; ; cartilage tissue; ; tendon of biceps brachii; ; left adrenal gland; ; right adrenal cortex; ; stromal cell of endometrium; ; left adrenal cortex; ; oocyte;
	Top expressed in
	urethra; ; muscle layer of urethra; ; bone marrow; ; vagina; ; yolk sac; ; epithelium of urethra; ; lamina propria of urethra; ; epithelium of female urethra; ; epiblast; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	endonuclease activity; nuclease activity; hydrolase activity; metal ion binding; protein binding; ribosome binding;
Cellular component	nucleus; cytoplasm;
Biological process	cell cycle; RNA surveillance; cell population proliferation; nuclear-transcribed mRNA catabolic process, non-stop decay; chromosome organization; nucleic acid phosphodiester bond hydrolysis; cell division; protein biosynthesis; endoderm development; stem cell population maintenance; positive regulation of BMP signaling pathway; ribosome disassembly; mesenchymal to epithelial transition; nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process, no-go decay; inner cell mass cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	53918
	105083
	ENSG00000152684
	ENSMUSG00000042275
	Q9BRX2
	Q80X73
	NM_015946
	NM_134058
	NP_057030
	NP_598819
	Wikidata
View/Edit Human	View/Edit Mouse

Protein pelota homolog (hPelogta) is a protein that in humans is encoded by the PELO gene.⁵⁶

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.⁶ In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering those stuck on mRNAs.⁷ It is a paralog of the release factor eRF1.

The Drosophila homolog was first discovered in 1993. Mutants exhibit G2/M arrest in meiosis and large nebenkern form in late spermatocytes.⁸ Human, yeast (Dom34), plant, and worm homologs are reported in 1995,⁹ followed by one found in archaea.¹⁰

References

GRCh38: Ensembl release 89: ENSG00000152684 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042275 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shamsadin R, Adham IM, von Beust G, Engel W (Nov 2000). "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics. 90 (1–2): 75–8. doi:10.1159/000015667. PMID 11060452. S2CID 35316587.
"Entrez Gene: PELO pelota homolog (Drosophila)".
van den Elzen AM, Schuller A, Green R, Séraphin B (February 2014). "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal. 33 (3): 265–76. doi:10.1002/embj.201386123. PMC 3989619. PMID 24424461.
Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, et al. (October 1993). "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics. 135 (2): 489–505. doi:10.1093/genetics/135.2.489. PMC 1205651. PMID 8244010.
Eberhart CG, Wasserman SA (October 1995). "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development. 121 (10): 3477–86. doi:10.1242/dev.121.10.3477. PMID 7588080.
Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF (November 1996). "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters. 144 (2–3): 151–5. doi:10.1111/j.1574-6968.1996.tb08522.x. PMID 8900058.

Further reading

Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ (2007). "Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (9–10): 546–58. doi:10.1016/j.bbaexp.2007.06.004. PMC 2682338. PMID 17669516.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152684 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042275 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11060452-5] Shamsadin R, Adham IM, von Beust G, Engel W (Nov 2000). "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics. 90 (1–2): 75–8. doi:10.1159/000015667. PMID 11060452. S2CID 35316587.

[entrez-6] "Entrez Gene: PELO pelota homolog (Drosophila)".

[7] van den Elzen AM, Schuller A, Green R, Séraphin B (February 2014). "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal. 33 (3): 265–76. doi:10.1002/embj.201386123. PMC 3989619. PMID 24424461.

[8] Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, et al. (October 1993). "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics. 135 (2): 489–505. doi:10.1093/genetics/135.2.489. PMC 1205651. PMID 8244010.

[9] Eberhart CG, Wasserman SA (October 1995). "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development. 121 (10): 3477–86. doi:10.1242/dev.121.10.3477. PMID 7588080.

[10] Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF (November 1996). "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters. 144 (2–3): 151–5. doi:10.1111/j.1574-6968.1996.tb08522.x. PMID 8900058.

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