PDLIM5

PDLIM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2UZC, 2DAR
Identifiers
Aliases	PDLIM5, ENH, ENH1, LIM, L9, PDZ and LIM domain 5
External IDs	OMIM: 605904; MGI: 1927489; HomoloGene: 21289; GeneCards: PDLIM5; OMA:PDLIM5 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	94,668,227 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	142,101,457 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; triceps brachii muscle; ; glutes; ; thoracic diaphragm; ; Epithelium of choroid plexus; ; muscle of thigh; ; gastrocnemius muscle; ; body of tongue;
	Top expressed in
	soleus muscle; ; myocardium of ventricle; ; atrioventricular valve; ; muscle of thigh; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; interventricular septum; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; protein N-terminus binding; actin binding; actinin binding; protein kinase C binding; cadherin binding involved in cell-cell adhesion; muscle alpha-actinin binding;
Cellular component	cytoplasm; cell junction; neuron projection; postsynaptic membrane; plasma membrane; synapse; actin cytoskeleton; membrane; postsynaptic density; cytosol; stress fiber; Z discdkac; filamentous actin;
Biological process	regulation of dendritic spine morphogenesis; regulation of synapse assembly; cell-cell adhesion; cell growth involved in cardiac muscle cell development; development of the heart; actin cytoskeleton organization; muscle structure development;
	Sources:Amigo / QuickGO
Orthologs
	10611
	56376
	ENSG00000163110
	ENSMUSG00000028273
	Q96HC4
	Q8CI51
NM_001011513; NM_001011515; NM_001011516; NM_001256425; NM_001256426;
	NM_001256427; NM_001256428; NM_001256429; NM_006457
NM_001190852; NM_001190853; NM_001190854; NM_001190855; NM_001190856;
	NM_001190857; NM_019808; NM_019809; NM_022554
NP_001011513; NP_001011515; NP_001011516; NP_001243354; NP_001243355;
	NP_001243356; NP_001243357; NP_001243358; NP_006448
NP_001177781; NP_001177782; NP_001177783; NP_001177784; NP_001177785;
	NP_001177786; NP_062782; NP_062783; NP_072048
	Wikidata
View/Edit Human	View/Edit Mouse

PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.⁵⁶

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N-terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.⁶

Interactions

PDLIM5 has been shown to interact with PRKCB1.⁷

References

GRCh38: Ensembl release 89: ENSG00000163110 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028273 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (September 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq. 15 (2): 144–7. doi:10.1080/10425170310001656756. PMID 15346770. S2CID 36916587.
"Entrez Gene: PDLIM5 PDZ and LIM domain 5".
Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. ISSN 0021-9258. PMID 8940095.

Further reading

Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics. 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Kuroda S, Tokunaga C, Kiyohara Y, et al. (1997). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID 8940095.
Ueki N, Seki N, Yano K, et al. (1999). "Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH)". J. Hum. Genet. 44 (4): 256–60. doi:10.1007/s100380050155. PMID 10429367.
Nakagawa N, Hoshijima M, Oyasu M, et al. (2000). "ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain". Biochem. Biophys. Res. Commun. 272 (2): 505–12. doi:10.1006/bbrc.2000.2787. PMID 10833443.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Maeno-Hikichi Y, Chang S, Matsumura K, et al. (2003). "A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels". Nat. Neurosci. 6 (5): 468–75. doi:10.1038/nn1041. PMID 12665800. S2CID 19964052.
Iwamoto K, Kakiuchi C, Bundo M, et al. (2004). "Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders". Mol. Psychiatry. 9 (4): 406–16. doi:10.1038/sj.mp.4001437. PMID 14743183.
Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
Iwamoto K, Bundo M, Washizuka S, et al. (2004). "Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia". J. Hum. Genet. 49 (5): 227–31. doi:10.1007/s10038-004-0136-5. PMID 15362566.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Niederländer N, Fayein NA, Auffray C, Pomiès P (2005). "Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 325 (4): 1304–11. doi:10.1016/j.bbrc.2004.10.178. PMID 15555569.
Kato T, Iwayama Y, Kakiuchi C, et al. (2005). "Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia". Mol. Psychiatry. 10 (11): 1045–55. doi:10.1038/sj.mp.4001719. PMID 16044170.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Horiuchi Y, Arai M, Niizato K, et al. (2006). "A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia". Biol. Psychiatry. 59 (5): 434–9. doi:10.1016/j.biopsych.2005.07.041. PMID 16213469. S2CID 22930796.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163110 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028273 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15346770-5] Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (September 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq. 15 (2): 144–7. doi:10.1080/10425170310001656756. PMID 15346770. S2CID 36916587.

[entrez-6] "Entrez Gene: PDLIM5 PDZ and LIM domain 5".

[pmid8940095-7] Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. ISSN 0021-9258. PMID 8940095.

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