PCSK4

PCSK4
Identifiers
Aliases	PCSK4, PC4, SPC5, proprotein convertase subtilisin/kexin type 4
External IDs	OMIM: 600487; MGI: 97514; HomoloGene: 22495; GeneCards: PCSK4; OMA:PCSK4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,490,752 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,329,498 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right uterine tube; ; testicle; ; anterior pituitary; ; right lobe of liver; ; right frontal lobe; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; olfactory zone of nasal mucosa;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; internal carotid artery; ; external carotid artery; ; neural layer of retina; ; outer nuclear layer; ; embryo; ; proximal tubule; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; protein binding; serine-type endopeptidase activity;
Cellular component	integral component of membrane; membrane; acrosomal membrane; cytoplasmic vesicle; acrosomal vesicle; trans-Golgi network; integral component of Golgi membrane;
Biological process	proteolysis; binding of sperm to zona pellucida; sperm capacitation; acrosome reaction; fertilization; reproductive process; protein processing; peptide hormone processing;
	Sources:Amigo / QuickGO
Orthologs
	54760
	18551
	ENSG00000115257
	ENSMUSG00000020131
	Q6UW60
	P29121
	NM_017573; NM_001395257
	NM_008793
	NP_060043
	NP_032819
	Wikidata
View/Edit Human	View/Edit Mouse

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020131 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID 7782070.
"Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

Further reading

Seidah NG, Chrétien M, Day R (1995). "The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions". Biochimie. 76 (3–4): 197–209. doi:10.1016/0300-9084(94)90147-3. PMID 7819324.
Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). "The proprotein convertases furin and PACE4 play a significant role in tumor progression". Mol. Carcinog. 28 (2): 63–9. doi:10.1002/1098-2744(200006)28:2<63::AID-MC1>3.0.CO;2-C. PMID 10900462. S2CID 22849623.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Mol. Cell. 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.
Li M, Mbikay M, Nakayama K, et al. (2001). "Prohormone convertase PC4 processes the precursor of PACAP in the testis". Ann. N. Y. Acad. Sci. 921: 333–9. doi:10.1111/j.1749-6632.2000.tb06988.x. PMID 11193847. S2CID 46125753.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Qiu Q, Basak A, Mbikay M, et al. (2005). "Role of pro-IGF-II processing by proprotein convertase 4 in human placental development". Proc. Natl. Acad. Sci. U.S.A. 102 (31): 11047–52. Bibcode:2005PNAS..10211047Q. doi:10.1073/pnas.0502357102. PMC 1182422. PMID 16040806.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020131 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7782070-5] Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID 7782070.

[entrez-6] "Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

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