PCGF6

PCGF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DJB
Identifiers
Aliases	PCGF6, MBLR, RNF134, polycomb group ring finger 6
External IDs	OMIM: 607816; MGI: 1918291; HomoloGene: 12378; GeneCards: PCGF6; OMA:PCGF6 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	103,351,144 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	47,039,345 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; gastrocnemius muscle; ; testicle; ; skeletal muscle tissue; ; stromal cell of endometrium; ; smooth muscle tissue; ; ganglionic eminence; ; tibial arteries; ; muscle layer of sigmoid colon;
	Top expressed in
	zygote; ; spermatocyte; ; primary oocyte; ; secondary oocyte; ; epiblast; ; seminiferous tubule; ; primitive streak; ; Rostral migratory stream; ; embryo; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding;
Cellular component	nucleus; PcG protein complex; nucleoplasm; PRC1 complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; histone H2A-K119 monoubiquitination; negative regulation of G0 to G1 transition; negative regulation of transcription, DNA-templated; inactivation of X chromosome by genetic imprinting;
	Sources:Amigo / QuickGO
Orthologs
	84108
	71041
	ENSG00000156374
	ENSMUSG00000025050
	Q9BYE7
	Q99NA9
	NM_001011663; NM_032154
	NM_027654; NM_001360632
	NP_001011663; NP_115530
	NP_081930; NP_001347561
	Wikidata
View/Edit Human	View/Edit Mouse

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.⁵⁶

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.⁶

References

GRCh38: Ensembl release 89: ENSG00000156374 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025050 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF). Genes Cells. 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. hdl:2027.42/72663. PMID 12167161. S2CID 23060582.
"Entrez Gene: PCGF6 polycomb group ring finger 6".

Further reading

Kanno M, Hasegawa M, Ishida A, et al. (1996). "mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity". EMBO J. 14 (22): 5672–8. doi:10.1002/j.1460-2075.1995.tb00254.x. PMC 394682. PMID 8521824.
Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMC 29289. PMID 11171983.
Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. doi:10.1242/dev.129.18.4171. PMID 12183370.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhong N, Radu G, Ju W, Brown WT (2006). "Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C". Biochem. Biophys. Res. Commun. 338 (2): 855–61. doi:10.1016/j.bbrc.2005.10.020. PMID 16248985.
Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein". Cell. 128 (5): 877–87. doi:10.1016/j.cell.2007.02.004. PMID 17320162. S2CID 6519228.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156374 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025050 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12167161-5] Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF). Genes Cells. 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. hdl:2027.42/72663. PMID 12167161. S2CID 23060582.

[entrez-6] "Entrez Gene: PCGF6 polycomb group ring finger 6".

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