PCBD2

PCBD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C45
Identifiers
Aliases	PCBD2, DCOH2, DCOHM, PHS2, pterin-4 alpha-carbinolamine dehydratase 2
External IDs	OMIM: 609836; MGI: 1919812; HomoloGene: 49987; GeneCards: PCBD2; OMA:PCBD2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	135,007,959 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,924,643 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; muscle of thigh; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; endothelial cell; ; Skeletal muscle tissue of rectus abdominis; ; left ventricle;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; primary oocyte; ; Epithelium of choroid plexus; ; facial motor nucleus; ; vestibular membrane of cochlear duct; ; proximal tubule; ; right kidney; ; yolk sac; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; phenylalanine 4-monooxygenase activity; lyase activity;
Cellular component	nucleus; cellular component;
Biological process	tetrahydrobiopterin biosynthetic process; positive regulation of transcription, DNA-templated; protein homotetramerization; protein heterooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	84105
	72562
	ENSG00000132570
	ENSMUSG00000021496
	Q9H0N5
	Q9CZL5
	NM_032151
	NM_028281
	NP_115527
	NP_082557
	Wikidata
View/Edit Human	View/Edit Mouse

Pterin-4-alpha-carbinolamine dehydratase 2 is an enzyme that in humans is encoded by the PCBD2 gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000132570 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021496 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T (Jun 2004). "Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2". Biochemistry. 43 (23): 7345–55. doi:10.1021/bi049620t. PMID 15182178.
Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J Biol Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.
"Entrez Gene: PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Arias JM, Murbartián J, Perez-Reyes E (2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Schaaf CP, Benzing J, Schmitt T, et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB J. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961. S2CID 17142907.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132570 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021496 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15182178-5] Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T (Jun 2004). "Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2". Biochemistry. 43 (23): 7345–55. doi:10.1021/bi049620t. PMID 15182178.

[pmid11980910-6] Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J Biol Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.

[entrez-7] "Entrez Gene: PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2".

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