OTUD7B

OTUD7B
Identifiers
Aliases	OTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDs	OMIM: 611748; MGI: 2654703; HomoloGene: 10624; GeneCards: OTUD7B; OMA:OTUD7B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,010,726 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,068,446 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; internal globus pallidus; ; sural nerve; ; secondary oocyte; ; tendon of biceps brachii; ; corpus callosum; ; inferior ganglion of vagus nerve; ; C1 segment; ; Skeletal muscle tissue of biceps brachii; ; epithelium of colon;
	Top expressed in
	blood; ; retinal pigment epithelium; ; sciatic nerve; ; right lung lobe; ; neural layer of retina; ; spermatid; ; lumbar subsegment of spinal cord; ; spermatocyte; ; triceps brachii muscle; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; cysteine-type peptidase activity; zinc ion binding; metal ion binding; peptidase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; thiol-dependent deubiquitinase; hydrolase activity; Lys48-specific deubiquitinase activity;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	mucosal immune response; negative regulation of protein localization to nucleus; protein K48-linked deubiquitination; protein deubiquitination involved in ubiquitin-dependent protein catabolic process; immune system process; negative regulation of transcription by RNA polymerase II; negative regulation of I-kappaB kinase/NF-kappaB signaling; proteolysis; negative regulation of interleukin-8 production; protein K63-linked deubiquitination; immune response; protein deubiquitination; protein K11-linked deubiquitination; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	56957
	229603
	ENSG00000264522
	ENSMUSG00000038495
	Q6GQQ9
	B2RUR8
	NM_020205
	NM_001025613; NM_001025614
	NP_064590
	NP_001020784; NP_001020785
	Wikidata
View/Edit Human	View/Edit Mouse

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000264522 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038495 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.
"Entrez Gene: OTUD7B OTU domain containing 7B".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Evans PC, Ovaa H, Hamon M, et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity". Biochem. J. 378 (Pt 3): 727–34. doi:10.1042/BJ20031377. PMC 1224040. PMID 14748687.
Evans PC, Smith TS, Lai MJ, et al. (2003). "A novel type of deubiquitinating enzyme". Journal of Biological Chemistry. 278 (25): 23180–6. doi:10.1074/jbc.M301863200. PMID 12682062.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000264522 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038495 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11463333-5] Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.

[entrez-6] "Entrez Gene: OTUD7B OTU domain containing 7B".

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