OSTF1

OSTF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X2K, 1ZLM, 3EHQ, 3EHR
Identifiers
Aliases	OSTF1, OSF, SH3P2, bA235O14.1, osteoclast stimulating factor 1
External IDs	OMIM: 610180; MGI: 700012; HomoloGene: 8227; GeneCards: OSTF1; OMA:OSTF1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	75,147,265 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	18,609,187 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; right lung; ; skin of abdomen; ; spleen; ; upper lobe of left lung; ; skin of leg; ; gallbladder; ; rectum;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; decidua; ; right kidney; ; gastrula; ; spleen; ; Ileal epithelium; ; lip; ; corneal stroma; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding;
Cellular component	cytoplasm; intracellular anatomical structure; secretory granule lumen; ficolin-1-rich granule lumen; extracellular region;
Biological process	ossification; signal transduction; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	26578
	20409
	ENSG00000134996
	ENSMUSG00000024725
	Q92882
	Q62422
	NM_012383
	NM_017375
	NP_036515
	NP_059071
	Wikidata
View/Edit Human	View/Edit Mouse

Osteoclast-stimulating factor 1 is a protein that in humans is encoded by the OSTF1 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000134996 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024725 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol. 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID 10092216. S2CID 34911988.
"Entrez Gene: OSTF1 osteoclast stimulating factor 1".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sparks AB, Hoffman NG, McConnell SJ, et al. (1998). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nat. Biotechnol. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID 9630982. S2CID 11166026.
Schaub R, Dupont B, Roodman GD, et al. (2000). "Assignment of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 87–8. doi:10.1159/000015492. PMID 10773673. S2CID 41580372.
Kurihara N, Menaa C, Maeda H, et al. (2001). "Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation". J. Biol. Chem. 276 (44): 41035–9. doi:10.1074/jbc.M100233200. PMID 11551898.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Szymkiewicz I, Destaing O, Jurdic P, Dikic I (2004). "SH3P2 in complex with Cbl and Src". FEBS Lett. 565 (1–3): 33–8. doi:10.1016/j.febslet.2004.03.100. PMID 15135048. S2CID 22127534.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Li M, Meng Z, Xu Y, et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor". Acta Crystallographica Section F. 61 (Pt 1): 128–30. doi:10.1107/S1744309104031653. PMC 1952375. PMID 16508112.
Chen L, Wang Y, Wells D, et al. (2006). "Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution". Acta Crystallographica Section F. 62 (Pt 9): 844–8. doi:10.1107/S1744309106030004. PMC 2242886. PMID 16946461.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134996 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024725 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10092216-5] Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol. 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID 10092216. S2CID 34911988.

[entrez-6] "Entrez Gene: OSTF1 osteoclast stimulating factor 1".

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