NOC2L

NOC2L
Identifiers
Aliases	NOC2L, NET15, NET7, NIR, PPP1R112, NOC2 like nucleolar associated transcriptional repressor
External IDs	OMIM: 610770; MGI: 1931051; HomoloGene: 6980; GeneCards: NOC2L; OMA:NOC2L - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	959,309 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	156,332,073 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left testis; ; right testis; ; right hemisphere of cerebellum; ; skin of leg; ; gastrocnemius muscle; ; skin of abdomen; ; anterior pituitary; ; right lobe of liver; ; canal of the cervix;
	Top expressed in
	ectoderm; ; otic vesicle; ; otic placode; ; saccule; ; tail of embryo; ; epiblast; ; yolk sac; ; ventricular zone; ; genital tubercle; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone binding; nucleosome binding; chromatin binding; protein binding; transcription corepressor activity; RNA binding;
Cellular component	Noc1p-Noc2p complex; Noc2p-Noc3p complex; nucleolus; nucleus; nucleoplasm; cytosol;
Biological process	cellular response to UV; negative regulation of B cell apoptotic process; negative regulation of histone acetylation; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of intrinsic apoptotic signaling pathway; apoptotic process; ribosomal large subunit biogenesis; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	26155
	57741
	ENSG00000188976
	ENSMUSG00000095567
	Q9Y3T9
	Q9WV70
	NM_015658
	NM_021303; NM_001369270
	NP_056473
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleolar complex protein 2 homolog is a protein that in humans is encoded by the NOC2L gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000188976 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000095567 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hublitz P, Kunowska N, Mayer UP, et al. (2006). "NIR is a novel INHAT repressor that modulates the transcriptional activity of p53". Genes Dev. 19 (23): 2912–24. doi:10.1101/gad.351205. PMC 1315397. PMID 16322561.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188976 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000095567 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)".

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