Glycylpeptide N-tetradecanoyltransferase 2

NMT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C2X
Identifiers
Aliases	NMT2, N-myristoyltransferase 2
External IDs	OMIM: 603801; MGI: 1202298; HomoloGene: 101539; GeneCards: NMT2; OMA:NMT2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	15,168,693 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	3,329,914 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ventricular zone; ; adipose tissue; ; subcutaneous adipose tissue; ; cerebellar hemisphere; ; ganglionic eminence; ; right hemisphere of cerebellum; ; abdominal fat; ; tibia; ; lateral nuclear group of thalamus;
	Top expressed in
	cumulus cell; ; substantia nigra; ; Rostral migratory stream; ; medial dorsal nucleus; ; medullary collecting duct; ; medial geniculate nucleus; ; atrioventricular valve; ; retinal pigment epithelium; ; lateral geniculate nucleus; ; condyle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; acyltransferase activity; glycylpeptide N-tetradecanoyltransferase activity;
Cellular component	cytoplasm; plasma membrane; Golgi apparatus; membrane; extrinsic component of membrane; cytosol; host cell;
Biological process	regulation of rhodopsin mediated signaling pathway; intracellular transport of virus; N-terminal protein myristoylation; N-terminal peptidyl-glycine N-myristoylation;
	Sources:Amigo / QuickGO
Orthologs
	9397
	18108
	ENSG00000152465
	ENSMUSG00000026643
	O60551
	O70311
	NM_001308295; NM_004808
	NM_001290368; NM_001290369; NM_001290370; NM_008708
	NP_001295224; NP_004799
	NP_001277297; NP_001277298; NP_001277299; NP_032734
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
PDB	IPR022676 PF01233 (ECOD; PDBsum)
AlphaFold	IPR022676; PF01233;

Human N-myristoyltransferase 2
Human N-myristoyltransferase 2
	Human N-myristoyltransferase isoform 2 (NMT2) (based on PDB: 4c2x)
Identifiers
Symbol	NMT2
Pfam	PF01233
InterPro	IPR022676
PDB
Available protein structures:
PDB	IPR022676 PF01233 (ECOD; PDBsum)
AlphaFold	IPR022676; PF01233;

Glycylpeptide N-tetradecanoyltransferase 2 known also as N-myristoyltransferase, is an enzyme (EC: 2.3.1.97) that in humans is encoded by the NMT2 gene.⁵

Function

N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The 496-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.⁶

Interactions

NMT2 has been shown to interact with:

caspase 3⁷
MARCKS⁸

References

GRCh38: Ensembl release 89: ENSG00000152465 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026643 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Giang DK, Cravatt BF (Apr 1998). "A second mammalian N-myristoyltransferase". J Biol Chem. 273 (12): 6595–8. doi:10.1074/jbc.273.12.6595. PMID 9506952.
Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW (2014). "Global profiling of co- and post-translationally N-myristoylated proteomes in human cells". Nat Commun. 5: 4919. Bibcode:2014NatCo...5.4919T. doi:10.1038/ncomms5919. PMC 4200515. PMID 25255805.
Selvakumar P, Sharma RK (2007). "Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)". Int J Mol Med. 19 (5): 823–7. doi:10.3892/ijmm.19.5.823. PMID 17390089.
Selvakumar P, Lakshmikuttyamma A, Sharma RK (2009). "Biochemical characterization of bovine brain myristoyl-CoA:protein N-myristoyltransferase type 2". J Biomed Biotechnol. 2009 907614. doi:10.1155/2009/907614. PMC 2737134. PMID 19746168.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152465 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026643 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9506952-5] Giang DK, Cravatt BF (Apr 1998). "A second mammalian N-myristoyltransferase". J Biol Chem. 273 (12): 6595–8. doi:10.1074/jbc.273.12.6595. PMID 9506952.

[6] Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW (2014). "Global profiling of co- and post-translationally N-myristoylated proteomes in human cells". Nat Commun. 5: 4919. Bibcode:2014NatCo...5.4919T. doi:10.1038/ncomms5919. PMC 4200515. PMID 25255805.

[7] Selvakumar P, Sharma RK (2007). "Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)". Int J Mol Med. 19 (5): 823–7. doi:10.3892/ijmm.19.5.823. PMID 17390089.

[8] Selvakumar P, Lakshmikuttyamma A, Sharma RK (2009). "Biochemical characterization of bovine brain myristoyl-CoA:protein N-myristoyltransferase type 2". J Biomed Biotechnol. 2009 907614. doi:10.1155/2009/907614. PMC 2737134. PMID 19746168.

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Glycylpeptide N-tetradecanoyltransferase 2

Function

Interactions

See also

References

Further reading

External links