Mucin 5AC

MUC5AC
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	5AJN, 5AJP, 5AJO
Identifiers
Aliases	MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs	OMIM: 158373; MGI: 104697; HomoloGene: 137237; GeneCards: MUC5AC; OMA:MUC5AC - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,201,138 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,372,968 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; gastric mucosa; ; body of stomach; ; fundus; ; gallbladder; ; canal of the cervix; ; islet of Langerhans; ; appendix; ; urinary bladder; ; muscle tissue;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; conjunctival fornix; ; duodenum; ; olfactory epithelium; ; quadriceps femoris muscle; ; esophagus; ; cornea; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular matrix structural constituent;
Cellular component	cytoplasm; Golgi lumen; extracellular region; extracellular exosome; extracellular space; plasma membrane; mucus layer;
Biological process	phosphatidylinositol-mediated signaling; O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4586
	17833
	ENSG00000215182; ENSG00000283158
	ENSMUSG00000037974
	P98088
	n/a
	NM_017511; NM_001304359
	NM_010844
	NP_001291288
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans.⁵⁶⁷

MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,⁸ and has also been associated with greater protection against influenza infection.⁹

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).¹⁰

References

ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037974 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, et al. (February 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". The Biochemical Journal. 305 (Pt 1): 211–219. doi:10.1042/bj3050211. PMC 1136451. PMID 7826332.
van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (June 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochemical and Biophysical Research Communications. 245 (3): 853–859. doi:10.1006/bbrc.1998.8535. PMID 9588204.
"Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231 116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150.
Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, et al. (October 2012). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. Bibcode:2012PNAS..10916528E. doi:10.1073/pnas.1206552109. PMC 3478656. PMID 23012413.
Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. 25 (19). Basel, Switzerland: 4437. doi:10.3390/molecules25194437. PMC 7582261. PMID 32992527.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC

[refGRCh38Ensembl-1] ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037974 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7826332-5] Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, et al. (February 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". The Biochemical Journal. 305 (Pt 1): 211–219. doi:10.1042/bj3050211. PMC 1136451. PMID 7826332.

[pmid9588204-6] van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (June 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochemical and Biophysical Research Communications. 245 (3): 853–859. doi:10.1006/bbrc.1998.8535. PMID 9588204.

[7] "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".

[Samsuzzaman_2019-8] Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231 116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150.

[9] Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, et al. (October 2012). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. Bibcode:2012PNAS..10916528E. doi:10.1073/pnas.1206552109. PMC 3478656. PMID 23012413.

[pmid32992527-10] Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. 25 (19). Basel, Switzerland: 4437. doi:10.3390/molecules25194437. PMC 7582261. PMID 32992527.

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