MTPN

MTPN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AAA
Identifiers
Aliases	MTPN, GCDP, V-1, myotrophin
External IDs	OMIM: 606484; MGI: 99445; HomoloGene: 40607; GeneCards: MTPN; OMA:MTPN - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	135,977,359 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	35,516,823 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; skin of arm; ; mucosa of ileum; ; myocardium of left ventricle; ; superficial temporal artery; ; monocyte; ; lower lobe of lung; ; trabecular bone; ; Brodmann area 46; ; tibialis anterior muscle;
	Top expressed in
	retinal pigment epithelium; ; Rostral migratory stream; ; barrel cortex; ; ciliary body; ; epithelium of lens; ; dorsal striatum; ; endothelial cell of lymphatic vessel; ; subiculum; ; prefrontal cortex; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding;
Cellular component	cytoplasm; F-actin capping protein complex; axon; perinuclear region of cytoplasm; nucleus; cytosol;
Biological process	regulation of striated muscle tissue development; catecholamine metabolic process; positive regulation of cardiac muscle hypertrophy; regulation of barbed-end actin filament capping; cellular response to mechanical stimulus; skeletal muscle tissue regeneration; neuron differentiation; striated muscle cell differentiation; regulation of translation; cerebellar granule cell differentiation; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell growth; positive regulation of macromolecule biosynthetic process; regulation of cell size;
	Sources:Amigo / QuickGO
Orthologs
	136319
	14489
	ENSG00000105887
	ENSMUSG00000029840
	P58546
	P62774
	NM_145808
	NM_008098
	NP_665807
	NP_032124
	Wikidata
View/Edit Human	View/Edit Mouse

Myotrophin is a protein that in humans is encoded by the MTPN gene.⁵⁶

Interactions

MTPN has been shown to interact with RELA⁷ and REL.⁷

References

GRCh38: Ensembl release 89: ENSG00000105887 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029840 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. doi:10.1159/000056974. PMID 11474205. S2CID 30646120.
"Entrez Gene: MTPN myotrophin".
Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26). United States: 23888–97. doi:10.1074/jbc.M202937200. ISSN 0021-9258. PMID 11971907.

Further reading

Taoka M, Yamakuni T, Song SY, et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif". Eur. J. Biochem. 207 (2): 615–20. doi:10.1111/j.1432-1033.1992.tb17088.x. PMID 1633812.
Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart". Circ. Res. 73 (1): 98–108. doi:10.1161/01.res.73.1.98. PMID 8508536.
Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro". J. Biol. Chem. 271 (5): 2812–6. doi:10.1074/jbc.271.5.2812. PMID 8576259.
Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy". J. Mol. Cell. Cardiol. 31 (4): 705–19. doi:10.1006/jmcc.1998.0903. PMID 10329199.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Knuefermann P, Chen P, Misra A, et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26): 23888–97. doi:10.1074/jbc.M202937200. PMID 11971907.
Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy". Biochim. Biophys. Acta. 1589 (3): 247–60. doi:10.1016/S0167-4889(02)00178-7. PMID 12031792.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Xiong Z, Liu E, Yan Y, et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions". J. Immunol. 177 (7): 4907–16. doi:10.4049/jimmunol.177.7.4907. PMC 3902139. PMID 16982933.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105887 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029840 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11474205-5] Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. doi:10.1159/000056974. PMID 11474205. S2CID 30646120.

[entrez-6] "Entrez Gene: MTPN myotrophin".

[pmid11971907-7] Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26). United States: 23888–97. doi:10.1074/jbc.M202937200. ISSN 0021-9258. PMID 11971907.

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