MTF1

MTF1
Identifiers
Aliases	MTF1, MTF-1, ZRF, metal-regulatory transcription factor 1, metal regulatory transcription factor 1
External IDs	OMIM: 600172; MGI: 101786; HomoloGene: 4347; GeneCards: MTF1; OMA:MTF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)1 Band 1p34.3 Start 37,809,574 bp1 End 37,859,592 bp1
Gene location (Mouse) Chr. Chromosome 4 (mouse)2 Band 4 D2.2|4 57.91 cM Start 124,695,897 bp2 End 124,743,593 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell mucosa of paranasal sinus oral cavity epithelium of bronchus bronchial epithelial cell nipple internal globus pallidus tendon of biceps brachii gums Top expressed in spermatid zygote spermatocyte seminiferous tubule secondary oocyte primary oocyte internal carotid artery motor neuron lacrimal gland retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding protein binding histone acetyltransferase binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm Biological process response to cadmium ion regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II response to metal ion response to oxidative stress transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II central nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4520 17764 Ensembl ENSG00000188786 ENSMUSG00000028890 UniProt Q14872 Q07243 RefSeq (mRNA) NM_005955 NM_008636 RefSeq (protein) NP_005946 NP_032662 Location (UCSC) Chr 1: 37.81 – 37.86 Mb Chr 4: 124.7 – 124.74 Mb PubMed search 3 4
Wikidata
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Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.⁵⁶

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).⁶