Article · Wikipedia archive · Last revised Jun 5, 2026

MPPF

MPPF, with the full name 2'-methoxyphenyl-(N-2'-pyridinyl)-p-fluoro-benzamidoethyipiperazine, is a compound that binds to the serotonin-1A receptor. Labeled with fluorine-18 it has been used as a radioligand with positron emission tomography. It has, e.g., been used to examine the difference in neuroreceptor binding in the human brain across sex and age.

Last revised
Jun 5, 2026
Read time
≈ 1 min
Length
203 w
Citations
2
Source
Wikipedia ↗
MPPF
source ↗
Names
Preferred IUPAC name
4-Fluoro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)benzamide
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3 ☒N
    Key: YJZYDPRMWYWYCG-UHFFFAOYSA-N ☒N
  • InChI=1/C25H27FN4O2/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20/h2-13H,14-19H2,1H3
    Key: YJZYDPRMWYWYCG-UHFFFAOYAQ
  • COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4=CC=C(C=C4)F
Properties
C25H27FN4O2
Molar mass 434.51 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

MPPF, with the full name 2'-methoxyphenyl-(N-2'-pyridinyl)-p-fluoro-benzamidoethyipiperazine, is a compound that binds to the serotonin-1A receptor. Labeled with fluorine-18 it has been used as a radioligand with positron emission tomography.1 It has, e.g., been used to examine the difference in neuroreceptor binding in the human brain across sex and age.2

See also

See also

References

References

  1. D. Le Bars (May 1998). "High-Yield Radiosynthesis and Preliminary In Vivo Evaluation of p-18FMPPF, a Fluoro Analog of WAY-100635". Nuclear Medicine and Biology. 25 (4): 343–350. doi:10.1016/S0969-8051(97)00229-1. PMID 9639295.
  2. Nicolas Costes; Merlet, I; Ostrowsky, K; Faillenot, I; Lavenne, F; Zimmer, L; Ryvlin, P; Le Bars, D (December 2005). "A18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging". The Journal of Nuclear Medicine. 46 (12): 1980–1989. PMID 16330560.