Article · Wikipedia archive · Last revised Jun 10, 2026

MMPIP

MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR7. This receptor subtype appears to be involved in the downstream response to cocaine in the brain.

Last revised
Jun 10, 2026
Read time
≈ 1 min
Length
153 w
Citations
2
Source
Wikipedia ↗
MMPIP
Two-dimensional molecular structure
Identifiers
  • 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H15N3O3
Molar mass333.347 g·mol−1
3D model (JSmol)
  • COc3ccc(cc3)C2CC(C1C(=O)N2C)ON=C1c4ccncc4
  (verify)

MMPIP is a drug used in scientific research that acts as a selective antagonist for the metabotropic glutamate receptor subtype mGluR7.1 This receptor subtype appears to be involved in the downstream response to cocaine in the brain.2

References

References

  1. Suzuki G, Tsukamoto N, Fushiki H, Kawagishi A, Nakamura M, Kurihara H, Mitsuya M, Ohkubo M, Ohta H (October 2007). "In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists". The Journal of Pharmacology and Experimental Therapeutics. 323 (1): 147–56. doi:10.1124/jpet.107.124701. PMID 17609420. S2CID 10402176.
  2. Li X, Li J, Peng XQ, Spiller K, Gardner EL, Xi ZX (June 2009). "Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism". Neuropsychopharmacology. 34 (7): 1783–96. doi:10.1038/npp.2008.236. PMC 3739975. PMID 19158667.